Genetics of Coronary Artery Disease: Discovery, Biology and Clinical Translation

Overview

Journal Nat Rev Genet

Specialty Genetics

Date 2017 Mar 14

PMID 28286336

Citations 265

Authors

Amit V Khera

Sekar Kathiresan

Affiliations

Soon will be listed here.

Abstract

Coronary artery disease is the leading global cause of mortality. Long recognized to be heritable, recent advances have started to unravel the genetic architecture of the disease. Common variant association studies have linked approximately 60 genetic loci to coronary risk. Large-scale gene sequencing efforts and functional studies have facilitated a better understanding of causal risk factors, elucidated underlying biology and informed the development of new therapeutics. Moving forwards, genetic testing could enable precision medicine approaches by identifying subgroups of patients at increased risk of coronary artery disease or those with a specific driving pathophysiology in whom a therapeutic or preventive approach would be most useful.

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