Proteolytic Activity in the Meibomian Gland: Implications to Health and Disease

Overview

Journal Exp Eye Res

Specialty Ophthalmology

Date 2017 Mar 13

PMID 28284957

Citations 1

Authors

Pablo Argueso

Affiliations

Soon will be listed here.

Abstract

The function of the meibomian gland in the upper and lower eyelids is critical to maintaining homeostasis at the ocular surface. Highly specialized meibocytes within the gland must differentiate and accumulate intracellular lipid droplets that are released into the tear film following rupture of the cell membrane. Proteases and their inhibitors have been recognized as key players in remodeling extracellular matrices and promoting the normal integrity of glandular tissue. They modulate a wide range of biological processes, such as cell proliferation and differentiation, and can contribute to disease when aberrantly expressed. Deciphering the role of proteolytic activity in the meibomian gland offers an opportunity to gain a more comprehensive and fundamental understanding of the developmental, physiological, and pathological processes associated with this gland.

Citing Articles

Meibomian Gland Dysfunction in Ocular Graft vs. Host Disease: A Need for Pre-Clinical Models and Deeper Insights.

Osae E, Steven P Int J Mol Sci. 2021; 22(7).

PMID: 33805326 PMC: 8036656. DOI: 10.3390/ijms22073516.

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