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Role of Bacille Calmette-Guérin in Preventing Tuberculous Infection

Overview
Journal Int J Tuberc Lung Dis
Specialty Pulmonary Medicine
Date 2017 Mar 13
PMID 28284257
Citations 1
Authors
S Adinarayanan
R K Culp
R Subramani
K M Abbas
S Radhakrishna
S Swaminathan
Affiliations
Soon will be listed here.
Abstract

Setting: Rural community in South India.

Objective: To determine the role of bacille Calmette-Guérin (BCG) in preventing tuberculous infection in children.

Design: A prevalence survey was undertaken in 1999-2001 in a representative rural population in Tiruvallur District in South India using cluster sampling. Tuberculin testing was performed among all children aged <15 years, and all adults aged 15 years were questioned about chest symptoms and underwent radiography, followed by sputum examinations, if indicated.

Results: In children living in households with a tuberculosis case, the proportion with evidence of tuberculous infection was 35.5% of 200 in the absence of a BCG scar and 27.0% of 100 in its presence, a reduction of 24% (P = 0.14). In very young children (age <5 years), the corresponding proportions were 29.1% of 55 and 11.9% of 42, a reduction of 59%; the difference was statistically significant (P = 0.048).

Conclusion: There is a possible role for BCG in preventing tuberculous infection in very young children.

Citing Articles

Prevalence of bacteriologically confirmed pulmonary tuberculosis and associated risk factors: A community survey in Thirvallur District, south India.

Dolla C, Dhanaraj B, Chandrasekaran P, Selvaraj S, Menon P, Thiruvengadam K PLoS One. 2021; 16(10):e0247245.

PMID: 34610012 PMC: 8491886. DOI: 10.1371/journal.pone.0247245.

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