The Synucleinopathies: Twenty Years On

Overview

Journal J Parkinsons Dis

Publisher Sage Publications

Specialty Neurology

Date 2017 Mar 12

PMID 28282814

Citations 262

Authors

Michel Goedert

Ross Jakes

Maria Grazia Spillantini

Affiliations

Soon will be listed here.

Abstract

In 2017, it is two hundred years since James Parkinson provided the first complete clinical description of the disease named after him, fifty years since the introduction of high-dose D,L-DOPA treatment and twenty years since α-synuclein aggregation came to the fore. In 1998, multiple system atrophy joined Parkinson's disease and dementia with Lewy bodies as the third major synucleinopathy. Here we review our work, which led to the identification of α-synuclein in Lewy bodies, Lewy neurites and Papp-Lantos bodies, as well as what has happened since. Some of the experiments described were carried out in collaboration with ML Schmidt, JQ Trojanowski and VMY Lee.

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