Current Evidence on Vitamin D Deficiency and Kidney Transplant: What's New?

Overview

Journal Rev Endocr Metab Disord

Publisher Springer

Specialty Endocrinology

Date 2017 Mar 11

PMID 28281103

Citations 14

Authors

Gerardo Sarno

Riccardo Nappi

Barbara Altieri

Giacomo Tirabassi

Emanuele Muscogiuri

Gianmaria Salvio

Stavroula A Paschou

Aristide Ferrara

Enrico Russo

Daniela Vicedomini

Cerbone Vincenzo

Andromachi Vryonidou

Silvia Della Casa

Giancarlo Balercia

Francesco Orio

Paride De Rosa

Affiliations

Soon will be listed here.

Abstract

Kidney transplant is the treatment of choice for end-stage chronic kidney disease. Kidneys generate 1,25-dihydroxyvitamin D (calcitriol) from 25-hydroxyvitamin D (calcidiol) for circulation in the blood to regulate calcium levels. Transplant patients with low calcidiol levels have an increased risk of metabolic and endocrine problems, cardiovascular disease, type 2 diabetes mellitus, poor graft survival, bone disorders, cancer, and mortality rate. The recommended calcidiol level after transplant is at least 30 ng/mL (75 nmol/L), which could require 1000-3000 IU/d vitamin D3 to achieve. Vitamin D3 supplementation studies have found improved endothelial function and acute rejection episodes. However, since kidney function may still be impaired, raising calcidiol levels may not lead to normal calcitriol levels. Thus, supplementation with calcitriol or an analog, alfacalcidiol, is often employed. Some beneficial effects found include possible improved bone health and reduced risk of chronic allograft nephropathy and cancer.

Citing Articles

Integrating Endocrine, Genomic, and Extra-Skeletal Benefits of Vitamin D into National and Regional Clinical Guidelines.

Wimalawansa S, Weiss S, Hollis B Nutrients. 2024; 16(22).

PMID: 39599755 PMC: 11597479. DOI: 10.3390/nu16223969.

Renal Organoids from Whole Kidney Cells.

Chen L Methods Mol Biol. 2024; 2764:157-164.

PMID: 38393594 DOI: 10.1007/978-1-0716-3674-9_11.

The Impact of Cholecaciferol Supplementation on Bone Mineral Density in Long-Term Kidney Transplant Recipients.

Battaglia Y, Bellasi A, Esposito P, Bortoluzzi A, Rotondi S, Andreucci M Biomolecules. 2023; 13(4).

PMID: 37189376 PMC: 10135898. DOI: 10.3390/biom13040629.

Cardiovascular Risk after Kidney Transplantation: Causes and Current Approaches to a Relevant Burden.

Reggiani F, Moroni G, Ponticelli C J Pers Med. 2022; 12(8).

PMID: 35893294 PMC: 9329988. DOI: 10.3390/jpm12081200.

Bone Mineral Density Changes in Long-Term Kidney Transplant Recipients: A Real-Life Cohort Study of Native Vitamin D Supplementation.

Battaglia Y, Bellasi A, Bortoluzzi A, Tondolo F, Esposito P, Provenzano M Nutrients. 2022; 14(2).

PMID: 35057505 PMC: 8780110. DOI: 10.3390/nu14020323.

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