Myeloid and T Cell-Derived TNF Protects Against Central Nervous System Tuberculosis

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2017 Mar 11

PMID 28280495

Citations 6

Authors

Nai-Jen Hsu

Ngiambudulu M Francisco

Roanne Keeton

Nasiema Allie

Valerie F J Quesniaux

Bernhard Ryffel

Muazzam Jacobs

Affiliations

Soon will be listed here.

Abstract

Tuberculosis of the central nervous system (CNS-TB) is a devastating complication of tuberculosis, and tumor necrosis factor (TNF) is crucial for innate immunity and controlling the infection. TNF is produced by many cell types upon activation, in particularly the myeloid and T cells during neuroinflammation. Here we used mice with TNF ablation targeted to myeloid and T cell (MT-TNF) to assess the contribution of myeloid and T cell-derived TNF in immune responses during CNS-TB. These mice exhibited impaired innate immunity and high susceptibility to cerebral infection, a similar phenotype to complete TNF-deficient mice. Further, MT-TNF mice were not able to control T cell responses and cytokine/chemokine production. Thus, our data suggested that collective TNF production by both myeloid and T cells are required to provide overall protective immunity against CNS-TB infection.

Citing Articles

Neutrophil-Mediated Immunopathology and Matrix Metalloproteinases in Central Nervous System - Tuberculosis.

Poh X, Loh F, Friedland J, Ong C Front Immunol. 2022; 12:788976.

PMID: 35095865 PMC: 8789671. DOI: 10.3389/fimmu.2021.788976.

Bioinformation Analysis Reveals IFIT1 as Potential Biomarkers in Central Nervous System Tuberculosis.

Qiao W, Fan J, Shang X, Wang L, Tuohetaerbaike B, Li Y Infect Drug Resist. 2022; 15:35-45.

PMID: 35027832 PMC: 8749771. DOI: 10.2147/IDR.S328197.

Immune control of Mycobacterium tuberculosis is dependent on both soluble TNFRp55 and soluble TNFRp75.

Keeton R, du Toit J, Hsu N, Dube F, Jacobs M Immunology. 2021; 164(3):524-540.

PMID: 34129695 PMC: 8517585. DOI: 10.1111/imm.13385.

Complete ablation of tumor necrosis factor decreases the production of IgA, IgG, and IgM in experimental central nervous system tuberculosis.

Francisco N, Allie N, Sebesho B, Ryffel B, Jacobs M Iran J Basic Med Sci. 2020; 23(5):680-690.

PMID: 32742607 PMC: 7374998. DOI: 10.22038/ijbms.2020.37947.9021.

Immunity Against Bacterial Infection of the Central Nervous System: An Astrocyte Perspective.

Geyer S, Jacobs M, Hsu N Front Mol Neurosci. 2019; 12:57.

PMID: 30894799 PMC: 6414802. DOI: 10.3389/fnmol.2019.00057.

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