Hospital-based Epidemiological and Clinical Characterisation of the Malignant Transformation of Oral Leukoplakia in a Chinese Population

Overview

Journal Int Dent J

Publisher Elsevier

Specialty Dentistry

Date 2017 Mar 10

PMID 28276054

Citations 5

Authors

Ming-Yue Lyu

Yu-Si Guo

Shuo Li

Di Yang

Hong Hua

Affiliations

Soon will be listed here.

Abstract

Objective: The aim of this review was to analyse, systematically, hospital-based epidemiological information concerning the malignant transformation rate (MTR) of oral leukoplakia (OL) in a Chinese population, as well as the associated risk factors.

Methods: Four electronic databases were searched for studies dealing with OL and related risk factors, including age, gender, type of lesion, site, and smoking and drinking habits.

Results: The MTR of OL in the hospital-based Chinese population ranged from 4% to 13%, based on the studies analysed. Regarding risk factors, we found that female patients had a higher MTR than male patients, and that patients older than 50 years of age also had a higher MTR. Patients who smoked had a lower MTR, while alcohol consumption seemed to have no association with MTR. Malignant transformation occurred most commonly on the tongue. Regarding lesion type, non-homogeneous OL had a higher MTR, with the granular type having the highest MTR. Our results regarding the epidemiology of OL showed a similar trend to those reported in western populations and provided preliminary epidemiological information on the Chinese population.

Conclusions: Our findings show that female gender, age >50 years and non-homogeneous OL are risk factors for malignant transformation. It is important to develop clinical strategies to educate, diagnose and treat patients with OL and to minimise the MTR of OL.

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