Dietary Flavonoids, CYP1A1 Genetic Variants, and the Risk of Colorectal Cancer in a Korean Population

Overview

Journal Sci Rep

Specialty Science

Date 2017 Mar 10

PMID 28273931

Citations 11

Authors

Young Ae Cho

Jeonghee Lee

Jae Hwan Oh

Hee Jin Chang

Dae Kyung Sohn

Aesun Shin

Jeongseon Kim

Affiliations

Soon will be listed here.

Abstract

The role of dietary flavonoid intake in colorectal carcinogenesis might differ according to flavonoid subclasses and individual genetic variants related to carcinogen metabolism. Therefore, we examined whether greater dietary intake of flavonoid subclasses was associated with a lower risk of colorectal cancer and whether CYP1A1 genetic variants altered this association. A semi-quantitative food frequency questionnaire was used to assess the dietary intake of six flavonoid subclasses (flavonols, flavones, flavanones, flavan-3-ols, anthocyanidins, and isoflavones) in 923 patients with colorectal cancer and 1,846 controls; furthermore, CYP1A1 genetic variants (rs4646903 and rs1048943) were genotyped. Among the subclasses of flavonoids, higher intake of flavonols and flavan-3-ols showed a stronger association with a reduced risk of colorectal cancer after adjusting for potential confounding factors. Carriers of the CYP1A1 rs4646903 CC homozygous variant showed a reduced risk of rectal cancer compared with that in TT carriers. The inverse association between dietary flavonol intake and colorectal cancer risk was stronger among carriers of the CC homozygous variant than among T allele carriers (P for interaction = 0.02), particularly for rectal cancer (P for interaction = 0.005). In conclusion, the effect of dietary flavonoid intake on colorectal cancer risk differs according to flavonoid subclasses and CYP1A1 genetic variants.

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References

Iacopetta B . Are there two sides to colorectal cancer?. Int J Cancer. 2002; 101(5):403-8. DOI: 10.1002/ijc.10635. View

Auton A, Brooks L, Durbin R, Garrison E, Kang H, Korbel J . A global reference for human genetic variation. Nature. 2015; 526(7571):68-74. PMC: 4750478. DOI: 10.1038/nature15393. View

Moon Y, Wang X, Morris M . Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Toxicol In Vitro. 2005; 20(2):187-210. DOI: 10.1016/j.tiv.2005.06.048. View

Manach C, Williamson G, Morand C, Scalbert A, Remesy C . Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr. 2005; 81(1 Suppl):230S-242S. DOI: 10.1093/ajcn/81.1.230S. View

Kyle J, Sharp L, Little J, Duthie G, McNeill G . Dietary flavonoid intake and colorectal cancer: a case-control study. Br J Nutr. 2009; 103(3):429-36. DOI: 10.1017/S0007114509991784. View

Hodek P, Trefil P, Stiborova M . Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450. Chem Biol Interact. 2002; 139(1):1-21. DOI: 10.1016/s0009-2797(01)00285-x. View

Chatuphonprasert W, Kondo S, Jarukamjorn K, Kawasaki Y, Sakuma T, Nemoto N . Potent modification of inducible CYP1A1 expression by flavonoids. Biol Pharm Bull. 2010; 33(10):1698-703. DOI: 10.1248/bpb.33.1698. View

Zamora-Ros R, Knaze V, Romieu I, Scalbert A, Slimani N, Clavel-Chapelon F . Impact of thearubigins on the estimation of total dietary flavonoids in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Eur J Clin Nutr. 2013; 67(7):779-82. DOI: 10.1038/ejcn.2013.89. View

Shin A, Kim K, Jung K, Park S, Won Y, Kim J . Increasing trend of colorectal cancer incidence in Korea, 1999-2009. Cancer Res Treat. 2013; 44(4):219-26. PMC: 3546268. DOI: 10.4143/crt.2012.44.4.219. View

10.

Huxley R, Ansary-Moghaddam A, Clifton P, Czernichow S, Parr C, Woodward M . The impact of dietary and lifestyle risk factors on risk of colorectal cancer: a quantitative overview of the epidemiological evidence. Int J Cancer. 2009; 125(1):171-80. DOI: 10.1002/ijc.24343. View

11.

Heim K, Tagliaferro A, Bobilya D . Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships. J Nutr Biochem. 2003; 13(10):572-584. DOI: 10.1016/s0955-2863(02)00208-5. View

12.

Liu T, Liang N, Li Y, Yang F, Lu Y, Meng Z . Effects of long-term tea polyphenols consumption on hepatic microsomal drug-metabolizing enzymes and liver function in Wistar rats. World J Gastroenterol. 2003; 9(12):2742-4. PMC: 4612044. DOI: 10.3748/wjg.v9.i12.2742. View

13.

Hwang C, Kwak H, Lim H, Lee S, Kang Y, Choe T . Isoflavone metabolites and their in vitro dual functions: they can act as an estrogenic agonist or antagonist depending on the estrogen concentration. J Steroid Biochem Mol Biol. 2006; 101(4-5):246-53. DOI: 10.1016/j.jsbmb.2006.06.020. View

14.

Zhu X, Wang Z, He J, Wang W, Xue W, Wang Y . Associations between CYP1A1 rs1048943 A > G and rs4646903 T > C genetic variations and colorectal cancer risk: Proof from 26 case-control studies. Oncotarget. 2016; 7(32):51365-51374. PMC: 5239481. DOI: 10.18632/oncotarget.10331. View

15.

Arts I, Jacobs Jr D, Gross M, Harnack L, Folsom A . Dietary catechins and cancer incidence among postmenopausal women: the Iowa Women's Health Study (United States). Cancer Causes Control. 2002; 13(4):373-82. DOI: 10.1023/a:1015290131096. View

16.

Hirvonen A, Husgafvel-Pursiainen K, Karjalainen A, Anttila S, Vainio H . Point-mutational MspI and Ile-Val polymorphisms closely linked in the CYP1A1 gene: lack of association with susceptibility to lung cancer in a Finnish study population. Cancer Epidemiol Biomarkers Prev. 1992; 1(6):485-9. View

17.

Jun S, Shin S, Joung H . Estimation of dietary flavonoid intake and major food sources of Korean adults. Br J Nutr. 2015; 115(3):480-9. DOI: 10.1017/S0007114515004006. View

18.

Landi M, Bertazzi P, Shields P, Clark G, Lucier G, Garte S . Association between CYP1A1 genotype, mRNA expression and enzymatic activity in humans. Pharmacogenetics. 1994; 4(5):242-6. DOI: 10.1097/00008571-199410000-00002. View

19.

Bobe G, Albert P, Sansbury L, Lanza E, Schatzkin A, Colburn N . Interleukin-6 as a potential indicator for prevention of high-risk adenoma recurrence by dietary flavonols in the polyp prevention trial. Cancer Prev Res (Phila). 2010; 3(6):764-75. PMC: 2881177. DOI: 10.1158/1940-6207.CAPR-09-0161. View

20.

Woo H, Lee J, Choi I, Kim C, Lee J, Kwon O . Dietary flavonoids and gastric cancer risk in a Korean population. Nutrients. 2014; 6(11):4961-73. PMC: 4245574. DOI: 10.3390/nu6114961. View