Screening of Peruvian Medicinal Plants for Tyrosinase Inhibitory Properties: Identification of Tyrosinase Inhibitors in Hypericum Laricifolium Juss

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2017 Mar 10

PMID 28273864

Citations 15

Authors

Yanymee Nimesia Guillen Quispe

Seung Hwan Hwang

Zhiqiang Wang

Soon Sung Lim

Affiliations

Soon will be listed here.

Abstract

Tyrosinase inhibitors are of far-ranging importance in cosmetics, medicinal products, and food industries. Peru is a diverse country with a wide variety of plants that may contain excellent anti-tyrosinase inhibitors. In the present study, the tyrosinase inhibitory properties of 50 medicinal plant extracts from Peru were investigated using tyrosinase assay. Among plant extracts, those that showed an inhibition rate >50% were JussF.H.Wigg and Meisn with Juss. showing the greatest anti-tyrosinase activity. Although Juss. has been widely used as a medicinal plant by Peruvians, little is known regarding its bioactive components and effects on tyrosinase activity. For this reason, we attempted to discover tyrosinase inhibitors in Juss. for the first time. The bioactive components were separated by Sephadex LH-20 chromatography and eluted with 100% methanol. Eight compounds were discovered and characterized by high-performance liquid chromatography coupled with diode array detection (HPLC-DAD): protocatechuic acid, -hydroxybenzoic acid, chlorogenic acid, vanilic acid, caffeic acid, kaempferol 3--glucuronide, quercetin, and kaempferol. In addition, the concentration of these compounds required for 50% inhibition (IC) of tyrosinase activity were evaluated. Quercetin exhibited the strongest tyrosinase inhibition (IC 14.29 ± 0.3 μM). Therefore, the Peruvian plant Juss. could be a novel source for anti-tyrosinase activity.

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