Controlling Self-assembly of Diphenylalanine Peptides at High PH Using Heterocyclic Capping Groups

Overview

Journal Sci Rep

Specialty Science

Date 2017 Mar 9

PMID 28272523

Citations 9

Authors

Adam D Martin

Jonathan P Wojciechowski

Andrew B Robinson

Celine Heu

Christopher J Garvey

Julian Ratcliffe

Lynne J Waddington

James Gardiner

Pall Thordarson

Affiliations

Soon will be listed here.

Abstract

Using small angle neutron scattering (SANS), it is shown that the existence of pre-assembled structures at high pH for a capped diphenylalanine hydrogel is controlled by the selection of N-terminal heterocyclic capping group, namely indole or carbazole. At high pH, changing from a somewhat hydrophilic indole capping group to a more hydrophobic carbazole capping group results in a shift from a high proportion of monomers to self-assembled fibers or wormlike micelles. The presence of these different self-assembled structures at high pH is confirmed through NMR and circular dichroism spectroscopy, scanning probe microscopy and cryogenic transmission electron microscopy.

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