A Possible Role for Neutrophils in Allergic Rhinitis Revealed After Cellular Subclassification

Overview

Journal Sci Rep

Specialty Science

Date 2017 Mar 9

PMID 28272395

Citations 24

Authors

Julia Arebro

Sandra Ekstedt

Eric Hjalmarsson

Ola Winqvist

Susanna Kumlien Georen

Lars-Olaf Cardell

Affiliations

Soon will be listed here.

Abstract

A re-examination of former concepts is required to meet today's medical challenges in allergic rhinitis. Previously, neutrophils have been treated as a relatively homogenous cell population found in the nose both when the patient is suffering at the height of the allergic season as well as when the patient report no symptoms. However, new data indicates that neutrophils can be divided into different subsets with diverse roles in inflammation. We showed increased levels of neutrophils in peripheral blood, nasal biopsies and nasal lavage fluid (NAL) from allergic patients during the pollen season compared to healthy controls. A closer examination revealed that the activated subset of neutrophils, CD16 CD62L, outweighed the normal form CD16 CD62L in nasal tissue among these patients. This skewed distribution was not seen in controls. The normal subset prevailed in peripheral blood from patients as well as controls, whereas CD16 CD62L and CD16 CD62L subsets, the latter considered "end state" neutrophils before apoptosis, were elevated in NAL. Functional in vitro experiments revealed that activated neutrophils exhibit a T cell priming capacity and an ability to enhance eosinophil migration. Activated neutrophils may thus contribute to allergic inflammation seen in allergic rhinitis by priming T cells and attracting eosinophils.

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