DNA Damage Response is Hijacked by Human Papillomaviruses to Complete Their Life Cycle

Overview

Journal J Zhejiang Univ Sci B

Specialties Biology
General Medicine

Date 2017 Mar 9

PMID 28271657

Citations 11

Authors

Shi-Yuan Hong

Affiliations

Soon will be listed here.

Abstract

The DNA damage response (DDR) is activated when DNA is altered by intrinsic or extrinsic agents. This pathway is a complex signaling network and plays important roles in genome stability, tumor transformation, and cell cycle regulation. Human papillomaviruses (HPVs) are the main etiological agents of cervical cancer. Cervical cancer ranks as the fourth most common cancer among women and the second most frequent cause of cancer-related death worldwide. Over 200 types of HPVs have been identified and about one third of these infect the genital tract. The HPV life cycle is associated with epithelial differentiation. Recent studies have shown that HPVs deregulate the DDR to achieve a productive life cycle. In this review, I summarize current findings about how HPVs mediate the ataxia-telangiectasia mutated kinase (ATM) and the ATM-and RAD3-related kinase (ATR) DDRs, and focus on the roles that ATM and ATR signalings play in HPV viral replication. In addition, I demonstrate that the signal transducer and activator of transcription-5 (STAT)-5, an important immune regulator, can promote ATM and ATR activations through different mechanisms. These findings may provide novel opportunities for development of new therapeutic targets for HPV-related cancers.

Citing Articles

Interactions among human papillomavirus proteins and host DNA repair factors differ during the viral life cycle and virus-induced tumorigenesis.

Wendel S, Wallace N mSphere. 2023; 8(6):e0042723.

PMID: 37850786 PMC: 10732048. DOI: 10.1128/msphere.00427-23.

Research progress on the role and mechanism of DNA damage repair in germ cell development.

Wang Y, Su M, Chen Y, Huang X, Ruan L, Lv Q Front Endocrinol (Lausanne). 2023; 14:1234280.

PMID: 37529603 PMC: 10390305. DOI: 10.3389/fendo.2023.1234280.

Effects of β-HPV on DNA damage response pathways to drive carcinogenesis: a review.

Tahseen D, Rady P, Tyring S Virus Genes. 2021; 57(1):23-30.

PMID: 33392984 DOI: 10.1007/s11262-020-01813-w.

Synergistic Carcinogenesis of HPV18 and MNNG in Het-1A Cells through p62-KEAP1-NRF2 and PI3K/AKT/mTOR Pathway.

Zhang Y, Ma Y, Zhao C, Zhang H, Pu Y, Yin L Oxid Med Cell Longev. 2020; 2020:6352876.

PMID: 33123313 PMC: 7586040. DOI: 10.1155/2020/6352876.

Pathogenesis of Human Papillomaviruses Requires the ATR/p62 Autophagy-Related Pathway.

Hong S, Li Y, Kaminski P, Andrade J, Laimins L mBio. 2020; 11(4).

PMID: 32788179 PMC: 7439466. DOI: 10.1128/mBio.01628-20.

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