Advancing Immune and Cell-Based Therapies Through Imaging

Overview

Journal Mol Imaging Biol

Publisher Springer

Specialties Molecular Biology
Radiology

Date 2017 Mar 9

PMID 28271366

Citations 11

Authors

Vladimir Ponomarev

Affiliations

Soon will be listed here.

Abstract

Immunotherapies include various approaches, ranging from stimulating effector mechanisms to counteracting inhibitory and suppressive mechanisms, and creating a forum for discussing the most effective means of advancing these therapies through imaging is the focus of the newly formed Imaging in Cellular and Immune Therapies (ICIT) interest group within the World Molecular Imaging Society. Efforts are being made in the identification and validation of predictive biomarkers for a number of immunotherapies. Without predictive biomarkers, a considerable number of patients may receive treatments that have no chance of offering a benefit. This will reflect poorly on the field of immunotherapy and will yield false hopes in patients while at the same time contributing to significant cost to the healthcare system. This review summarizes the main strategies in cancer immune and cell-based therapies and discusses recent advances in imaging strategies aimed to improve cancer immunotherapy outcomes.

Citing Articles

Imaging cellular immunotherapies and immune cell biomarkers: from preclinical studies to patients.

Volpe A, Adusumilli P, Schoder H, Ponomarev V J Immunother Cancer. 2022; 10(9).

PMID: 36137649 PMC: 9511655. DOI: 10.1136/jitc-2022-004902.

MRI techniques for immunotherapy monitoring.

Lau D, Corrie P, Gallagher F J Immunother Cancer. 2022; 10(9.

PMID: 36122963 PMC: 9486399. DOI: 10.1136/jitc-2022-004708.

Immune PET Imaging.

Iyalomhe O, Farwell M Radiol Clin North Am. 2021; 59(5):875-886.

PMID: 34392924 PMC: 8371717. DOI: 10.1016/j.rcl.2021.05.010.

Radionuclide-based molecular imaging allows CAR-T cellular visualization and therapeutic monitoring.

Shao F, Long Y, Ji H, Jiang D, Lei P, Lan X Theranostics. 2021; 11(14):6800-6817.

PMID: 34093854 PMC: 8171102. DOI: 10.7150/thno.56989.

Macrophage imaging and subset analysis using single-cell RNA sequencing.

Arlauckas S, Oh N, Li R, Weissleder R, Miller M Nanotheranostics. 2021; 5(1):36-56.

PMID: 33391974 PMC: 7738942. DOI: 10.7150/ntno.50185.

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