Autoantibodies Against Carbonic Anhydrase I and II in Patients with Acute Myeloid Leukemia

Overview

Journal Turk J Haematol

Specialty Hematology

Date 2017 Mar 9

PMID 28270370

Citations 3

Authors

Ahmet Mentese

Nergiz Erkut

Selim Demir

Serap Ozer Yaman

Aysegul Sumer

Seniz Dogramaci

Ahmet Alver

Mehmet Sonmez

Affiliations

Soon will be listed here.

Abstract

Objective: Cancer, one of the principal causes of death, is a global social health problem. Autoantibodies developed against the organism's self-antigens are detected in the sera of subjects with cancer. In recent years carbonic anhydrase (CA) I and II autoantibodies have been shown in some autoimmune diseases and carcinomas, but the mechanisms underlying this immune response have not yet been explained. The aim of this study was to evaluate CA I and II autoantibodies in patients with acute myeloid leukemia (AML) and to provide a novel perspective regarding the autoimmune basis of the disease.

Materials And Methods: Anti-CA I and II antibody levels were investigated using ELISA in serum samples from 30 patients with AML and 30 healthy peers.

Results: Anti-CA I and II antibody titers in the AML group were significantly higher compared with the control group (p=0.0001 and 0.018, respectively). A strong positive correlation was also determined between titers of anti-CA I and II antibodies (r=0.613, p=0.0001).

Conclusion: Our results suggest that these autoantibodies may be involved in the pathogenesis of AML. More extensive studies are now needed to reveal the entire mechanism.

Citing Articles

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Association between the expression of carbonic anhydrase II and clinicopathological features of hepatocellular carcinoma.

Zhang H, Zhuo C, Zhou D, Zhang F, Chen M, Xu S Oncol Lett. 2019; 17(6):5721-5728.

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The Human Carbonic Anhydrase II in Platelets: An Underestimated Field of Its Activity.

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