Immunological and Structural Homology Between Human T-cell Leukemia Virus Type I Envelope Glycoprotein and a Region of Human Interleukin-2 Implicated in Binding the Beta Receptor

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1988 Feb 1

PMID 2826824

Citations 6

Authors

D S Kohtz

A Altman

J D Kohtz

S Puszkin

Affiliations

Soon will be listed here.

Abstract

The N-terminal segment of human interleukin-2 (hIL-2) appears to mediate binding of the beta hIL-2 receptor (R. Robb, C. Rusk, J. Yodoi, and W. Greene, Proc. Natl. Acad. Sci. USA 84:2002-2006, 1987). An affinity-purified antibody prepared against this peptide segment (p81) is shown here to cross-react with a homologous region of the human T-cell leukemia virus type I (HTLV-I) envelope glycoprotein, raising the interesting possibility that the envelope glycoprotein of HTLV-I can interact with the beta hIL-2 receptor.

Citing Articles

Envelope is a major viral determinant of the distinct in vitro cellular transformation tropism of human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2.

Xie L, Green P J Virol. 2005; 79(23):14536-45.

PMID: 16282453 PMC: 1287554. DOI: 10.1128/JVI.79.23.14536-14545.2005.

Evolution of cell recognition by viruses: a source of biological novelty with medical implications.

Baranowski E, Ruiz-Jarabo C, Pariente N, Verdaguer N, Domingo E Adv Virus Res. 2004; 62:19-111.

PMID: 14719364 PMC: 7119103. DOI: 10.1016/s0065-3527(03)62002-6.

Characterization of new syncytium-inhibiting monoclonal antibodies implicates lipid rafts in human T-cell leukemia virus type 1 syncytium formation.

Niyogi K, Hildreth J J Virol. 2001; 75(16):7351-61.

PMID: 11462007 PMC: 114970. DOI: 10.1128/JVI.75.16.7351-7361.2001.

Mechanisms of T-cell activation by human T-cell lymphotropic virus type I.

Hollsberg P Microbiol Mol Biol Rev. 1999; 63(2):308-33.

PMID: 10357853 PMC: 98968. DOI: 10.1128/MMBR.63.2.308-333.1999.

71-kilodalton heat shock cognate protein acts as a cellular receptor for syncytium formation induced by human T-cell lymphotropic virus type 1.

Sagara Y, Ishida C, Inoue Y, Shiraki H, Maeda Y J Virol. 1998; 72(1):535-41.

PMID: 9420256 PMC: 109405. DOI: 10.1128/JVI.72.1.535-541.1998.

References

Rho H, Poiesz B, Ruscetti F, Gallo R . Characterization of the reverse transcriptase from a new retrovirus (HTLV) produced by a human cutaneous T-cell lymphoma cell line. Virology. 1981; 112(1):355-60. DOI: 10.1016/0042-6822(81)90642-5. View

Gootenberg J, Ruscetti F, Mier J, Gazdar A, Gallo R . Human cutaneous T cell lymphoma and leukemia cell lines produce and respond to T cell growth factor. J Exp Med. 1981; 154(5):1403-18. PMC: 2186515. DOI: 10.1084/jem.154.5.1403. View

Catovsky D, Greaves M, Rose M, GALTON D, GOOLDEN A, McCluskey D . Adult T-cell lymphoma-leukaemia in Blacks from the West Indies. Lancet. 1982; 1(8273):639-43. DOI: 10.1016/s0140-6736(82)92200-0. View

Popovic M, SARIN P, Kalyanaraman V, Mann D, Minowada J, Gallo R . Isolation and transmission of human retrovirus (human t-cell leukemia virus). Science. 1983; 219(4586):856-9. DOI: 10.1126/science.6600519. View

Taniguchi T, Matsui H, Fujita T, Takaoka C, Kashima N, Yoshimoto R . Structure and expression of a cloned cDNA for human interleukin-2. Nature. 1983; 302(5906):305-10. DOI: 10.1038/302305a0. View

Seiki M, Hattori S, Hirayama Y, Yoshida M . Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA. Proc Natl Acad Sci U S A. 1983; 80(12):3618-22. PMC: 394101. DOI: 10.1073/pnas.80.12.3618. View

Robb R, Rusk C, Yodoi J, Greene W . Interleukin 2 binding molecule distinct from the Tac protein: analysis of its role in formation of high-affinity receptors. Proc Natl Acad Sci U S A. 1987; 84(7):2002-6. PMC: 304571. DOI: 10.1073/pnas.84.7.2002. View

Altman A, Cardenas J, Houghten R, Dixon F, Theofilopoulos A . Antibodies of predetermined specificity against chemically synthesized peptides of human interleukin 2. Proc Natl Acad Sci U S A. 1984; 81(7):2176-80. PMC: 345460. DOI: 10.1073/pnas.81.7.2176. View

Kohtz D, Waksal S . Growth factors and leukemogenesis. A role for biological mimicry in biological transformation. Surv Immunol Res. 1984; 3(1):34-8. DOI: 10.1007/BF02918595. View

10.

Sodroski J, Patarca R, Perkins D, Briggs D, Lee T, Essex M . Sequence of the envelope glycoprotein gene of type II human T lymphotropic virus. Science. 1984; 225(4660):421-4. DOI: 10.1126/science.6204380. View

11.

Brown J, Twardzik D, Marquardt H, Todaro G . Vaccinia virus encodes a polypeptide homologous to epidermal growth factor and transforming growth factor. Nature. 1985; 313(6002):491-2. DOI: 10.1038/313491a0. View

12.

Geysen H, Barteling S, Meloen R . Small peptides induce antibodies with a sequence and structural requirement for binding antigen comparable to antibodies raised against the native protein. Proc Natl Acad Sci U S A. 1985; 82(1):178-82. PMC: 396995. DOI: 10.1073/pnas.82.1.178. View

13.

Matsushita S, Robert-Guroff M, Trepel J, Cossman J, Mitsuya H, Broder S . Human monoclonal antibody directed against an envelope glycoprotein of human T-cell leukemia virus type I. Proc Natl Acad Sci U S A. 1986; 83(8):2672-6. PMC: 323361. DOI: 10.1073/pnas.83.8.2672. View

14.

Lando Z, Sarin P, Megson M, Greene W, Waldman T, Gallo R . Association of human T-cell leukaemia/lymphoma virus with the Tac antigen marker for the human T-cell growth factor receptor. Nature. 1983; 305(5936):733-6. DOI: 10.1038/305733a0. View