Comparative Pharmacokinetic Profile of Cyclosporine (CsA) with a Decapeptide and a Linear Analogue

Overview

Journal Org Biomol Chem

Publisher Royal Society of Chemistry

Specialties Biochemistry
Chemistry

Date 2017 Mar 8

PMID 28266673

Citations 10

Authors

David A Price

Heather Eng

Kathleen A Farley

Gilles H Goetz

Yong Huang

Zhaodong Jiao

Amit S Kalgutkar

Natasha M Kablaoui

Bhagyashree Khunte

Spiros Liras

Chris Limberakis

Alan M Mathiowetz

Roger B Ruggeri

Jun-Min Quan

Zhen Yang

Affiliations

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Abstract

The synthesis and in vivo pharmacokinetic profile of an analogue of cyclosporine is disclosed. An acyclic congener was also profiled in in vitro assays to compare cell permeability. The compounds possess similar calculated and measured molecular descriptors however have different behaviors in an RRCK assay to assess cell permeability.

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