Studies of Prototype Live Hepatitis A Virus Vaccines in Primate Models

Overview

Journal J Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 1988 Feb 1

PMID 2826614

Citations 16

Authors

R A Karron

R Daemer

J Ticehurst

E Dhondt

H Popper

K Mihalik

J Phillips

S Feinstone

R H Purcell

Affiliations

Soon will be listed here.

Abstract

We have prepared two prototype live hepatitis A virus (HAV) vaccines by serial passage of the HM-175 strain of HAV in African green monkey kidney cells. Passage 21 (P-21) HM-175 virus shows evidence of attenuation for chimpanzees but not for marmosets; passage 32 (P-32) HM-175 virus shows evidence of attenuation for both species. Animals that received P-32 HAV had fewer elevations in levels of liver enzyme activity and evidence of less virus replication in the liver and excretion of virus in stool than did those that received wild-type virus. The P-21 and P-32 viruses were highly immunogenic in both species. The information provided by this study will aid in the development of a live HAV vaccine.

Citing Articles

Nonhuman Primate Models of Hepatitis A Virus and Hepatitis E Virus Infections.

Lanford R, Walker C, Lemon S Cold Spring Harb Perspect Med. 2018; 9(2).

PMID: 29686041 PMC: 6360867. DOI: 10.1101/cshperspect.a031815.

Immunization against Hepatitis A.

Shouval D Cold Spring Harb Perspect Med. 2018; 9(2).

PMID: 29661808 PMC: 6360863. DOI: 10.1101/cshperspect.a031682.

The Chimpanzee Model of Viral Hepatitis: Advances in Understanding the Immune Response and Treatment of Viral Hepatitis.

Lanford R, Walker C, Lemon S ILAR J. 2017; 58(2):172-189.

PMID: 29045731 PMC: 5886334. DOI: 10.1093/ilar/ilx028.

Live attenuated hepatitis A vaccines developed in China.

Xu Z, Wang X Hum Vaccin Immunother. 2013; 10(3):659-66.

PMID: 24280971 PMC: 4130259. DOI: 10.4161/hv.27124.

Chimpanzees as an animal model for human norovirus infection and vaccine development.

Bok K, Parra G, Mitra T, Abente E, Shaver C, Boon D Proc Natl Acad Sci U S A. 2010; 108(1):325-30.

PMID: 21173246 PMC: 3017165. DOI: 10.1073/pnas.1014577107.