Evaluation of Antinociceptive and Anti-inflammatory Effects of Aqueous Extract of Armadillidium Vulgare Latreille

Overview

Journal Chin J Integr Med

Date 2017 Mar 8

PMID 28265851

Citations 1

Authors

Shen-Shen Guo

Meng-Yue Ren

Shuai Song

Ping Wei

Jia-Bo Luo

Affiliations

Soon will be listed here.

Abstract

Objective: To assess the antinociceptive and anti-inflammatory properties of the aqueous extract of Armadillidium vulgare (AV).

Methods: The antinociceptive effect of AV (400, 600 and 800 mg/kg) was investigated in mice using the acetic acid-induced writhing, formalin-induced nociceptive, and hot plate tests. Phlogogen-induced paw edema using carrageenan, dextran, or compound 48/80 as phlogogen was used as inflammatory models to evaluate AV's anti-inflammatory effect. Additionally, the bioactive substances glucosamine (GLcN) and taurine in AV were determined using high-performance liquid chromatography.

Results: Oral treatment of the mice with AV (600 and 800 mg/kg) significantly reduced the number of writhes in the acetic acid-induced writhing test (P<0.01) but not the hot plate test (P>0.05). All doses tested significantly inhibited paw-withdrawal during the second phase of the formalin-induced nociceptive model (P<0.01). AV demonstrated a strong anti-inflammatory effect in all those inflammatory models (P<0.05).

Conclusions: AV has antinociceptive and anti-inflammatory effects, providing scientific evidence of the efficacy of its traditional use in pain treatment. Furthermore, GLcN and taurine contribute, at least in part, to the anti-inflammatory activity of AV.

Citing Articles

Genoprotective, antioxidant, antifungal and anti-inflammatory evaluation of hydroalcoholic extract of wild-growing Juniperus communis L. (Cupressaceae) native to Romanian southern sub-Carpathian hills.

Fierascu I, Ungureanu C, Avramescu S, Cimpeanu C, Georgescu M, Fierascu R BMC Complement Altern Med. 2018; 18(1):3.

PMID: 29301523 PMC: 5755145. DOI: 10.1186/s12906-017-2066-8.

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