Epigenetics in Stroke Recovery

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2017 Mar 8

PMID 28264471

Citations 19

Authors

Haifa Kassis

Amjad Shehadah

Michael Chopp

Zheng Gang Zhang

Affiliations

Soon will be listed here.

Abstract

While the death rate from stroke has continually decreased due to interventions in the hyperacute stage of the disease, long-term disability and institutionalization have become common sequelae in the aftermath of stroke. Therefore, identification of new molecular pathways that could be targeted to improve neurological recovery among survivors of stroke is crucial. Epigenetic mechanisms such as post-translational modifications of histone proteins and microRNAs have recently emerged as key regulators of the enhanced plasticity observed during repair processes after stroke. In this review, we highlight the recent advancements in the evolving field of epigenetics in stroke recovery.

Citing Articles

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Role of histone deacetylases and sirtuins in the ischaemic stroke: a protocol for a systematic review and meta-analysis of animal studies.

Majdi A, Mostafavi H, Moharrami A, Yaraghi S, Ghaffari Tabrizi A, Dojahani M Stroke Vasc Neurol. 2024; 10(1):129-135.

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Sharma V, Sharma P, Singh T Mol Biol Rep. 2024; 51(1):247.

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Minor Changes for a Major Impact: A Review of Epigenetic Modifications in Cell-Based Therapies for Stroke.

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