Influence of Vitamin D on Liver Fibrosis in Chronic Hepatitis C: A Systematic Review and Meta-analysis of the Pooled Clinical Trials Data

Overview

Journal World J Hepatol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2017 Mar 7

PMID 28261385

Citations 11

Authors

Alia S Dadabhai

Behnam Saberi

Katie Lobner

Russell T Shinohara

Gerard E Mullin

Affiliations

Soon will be listed here.

Abstract

Aim: To investigate the relationship between vitamin D and liver fibrosis in hepatitis C-monoinfected or hepatitis C virus (HCV)-human immunodeficiency virus (HIV) co-infected patients.

Methods: Pertinent studies were located by a library literature search in PubMed/Embase/Cochrane/Scopus/LILACS by two individual reviewers. Inclusion criteria: (1) studies with patients with HCV or co-infected HCV/HIV; (2) studies with patients ≥ 18 years old; (3) studies that evaluated liver fibrosis stage, only based on liver biopsy; and (4) studies that reported serum or plasma 25(OH)D levels. Studies that included pediatric patients, other etiologies of liver disease, or did not use liver biopsy for fibrosis evaluation, or studies with inadequate data were excluded. Estimated measures of association reported in the literature, as well as corresponding measures of uncertainty, were recorded and corresponding odds ratios with 95%CI were included in a meta-analysis.

Results: The pooled data of this systematic review showed that 9 of the 12 studies correlated advanced liver disease defined as a Metavir value of F3/4 with 25(OH) D level insufficiency. The meta-analysis indicated a significant association across studies.

Conclusion: Low vitamin D status is common in chronic Hepatitis C patients and is associated with advanced liver fibrosis.

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References

Balshem H, Helfand M, Schunemann H, Oxman A, Kunz R, Brozek J . GRADE guidelines: 3. Rating the quality of evidence. J Clin Epidemiol. 2011; 64(4):401-6. DOI: 10.1016/j.jclinepi.2010.07.015. View

Sebastiani G, Gkouvatsos K, Pantopoulos K . Chronic hepatitis C and liver fibrosis. World J Gastroenterol. 2014; 20(32):11033-53. PMC: 4145747. DOI: 10.3748/wjg.v20.i32.11033. View

Efe C, Kav T, Aydin C, Cengiz M, NasiroglU Imga N, Purnak T . Low serum vitamin D levels are associated with severe histological features and poor response to therapy in patients with autoimmune hepatitis. Dig Dis Sci. 2014; 59(12):3035-42. DOI: 10.1007/s10620-014-3267-3. View

McClave S, DiBaise J, Mullin G, Martindale R . ACG Clinical Guideline: Nutrition Therapy in the Adult Hospitalized Patient. Am J Gastroenterol. 2016; 111(3):315-34. DOI: 10.1038/ajg.2016.28. View

Deluca H . Vitamin D: Historical Overview. Vitam Horm. 2016; 100:1-20. DOI: 10.1016/bs.vh.2015.11.001. View

Kitson M, Button P, Roberts S . Reply to: "Vitamin D status does not predict sustained virologic response or fibrosis stage in chronic hepatitis C genotype 1 infection". J Hepatol. 2013; 59(1):194-5. DOI: 10.1016/j.jhep.2013.03.001. View

Ross A . The 2011 report on dietary reference intakes for calcium and vitamin D. Public Health Nutr. 2011; 14(5):938-9. DOI: 10.1017/S1368980011000565. View

Iruzubieta P, Teran A, Crespo J, Fabrega E . Vitamin D deficiency in chronic liver disease. World J Hepatol. 2014; 6(12):901-15. PMC: 4269909. DOI: 10.4254/wjh.v6.i12.901. View

Garcia-Alvarez M, Pineda-Tenor D, Jimenez-Sousa M, Fernandez-Rodriguez A, Guzman-Fulgencio M, Resino S . Relationship of vitamin D status with advanced liver fibrosis and response to hepatitis C virus therapy: a meta-analysis. Hepatology. 2014; 60(5):1541-50. DOI: 10.1002/hep.27281. View

10.

Agmon-Levin N, Kopilov R, Selmi C, Nussinovitch U, Sanchez-Castanon M, Lopez-Hoyos M . Vitamin D in primary biliary cirrhosis, a plausible marker of advanced disease. Immunol Res. 2014; 61(1-2):141-6. DOI: 10.1007/s12026-014-8594-0. View

11.

Mullin G . Micronutrients and inflammatory bowel disease. Nutr Clin Pract. 2012; 27(1):136-7. DOI: 10.1177/0884533611433436. View

12.

Terrier B, Carrat F, Geri G, Pol S, Piroth L, Halfon P . Low 25-OH vitamin D serum levels correlate with severe fibrosis in HIV-HCV co-infected patients with chronic hepatitis. J Hepatol. 2011; 55(4):756-61. DOI: 10.1016/j.jhep.2011.01.041. View

13.

Grunhage F, Hochrath K, Krawczyk M, Hoblinger A, Obermayer-Pietsch B, Geisel J . Common genetic variation in vitamin D metabolism is associated with liver stiffness. Hepatology. 2012; 56(5):1883-91. DOI: 10.1002/hep.25830. View

14.

Gatti D, Idolazzi L, Fassio A . Vitamin D: not just bone, but also immunity. Minerva Med. 2016; 107(6):452-460. View

15.

Mullin G, Dobs A . Vitamin d and its role in cancer and immunity: a prescription for sunlight. Nutr Clin Pract. 2007; 22(3):305-22. DOI: 10.1177/0115426507022003305. View

16.

Feldman D, Krishnan A, Swami S, Giovannucci E, Feldman B . The role of vitamin D in reducing cancer risk and progression. Nat Rev Cancer. 2014; 14(5):342-57. DOI: 10.1038/nrc3691. View

17.

Mullin G, Turnbull L, Kines K . Vitamin D: a D-lightful health supplement. Nutr Clin Pract. 2009; 24(5):642-4. DOI: 10.1177/0884533609343938. View

18.

Peterlik M, Cross H . Vitamin D and calcium deficits predispose for multiple chronic diseases. Eur J Clin Invest. 2005; 35(5):290-304. DOI: 10.1111/j.1365-2362.2005.01487.x. View

19.

Finkelmeier F, Kronenberger B, Zeuzem S, Piiper A, Waidmann O . Low 25-Hydroxyvitamin D Levels Are Associated with Infections and Mortality in Patients with Cirrhosis. PLoS One. 2015; 10(6):e0132119. PMC: 4487892. DOI: 10.1371/journal.pone.0132119. View

20.

Lange C, Bibert S, Kutalik Z, Burgisser P, Cerny A, Dufour J . A genetic validation study reveals a role of vitamin D metabolism in the response to interferon-alfa-based therapy of chronic hepatitis C. PLoS One. 2012; 7(7):e40159. PMC: 3395683. DOI: 10.1371/journal.pone.0040159. View