Gender Differences in the Association Between Gene Variants and Suicidal Behavior in a Mexican Population: a Case-control Study

Overview

Journal Neuropsychiatr Dis Treat

Publisher Dove Medical Press

Specialty Psychiatry

Date 2017 Mar 7

PMID 28260903

Citations 2

Authors

Gabriel Molina-Guzman

Thelma Beatriz Gonzalez-Castro

Yazmin Hernandez Diaz

Carlos Alfonso Tovilla-Zarate

Isela E Juarez-Rojop

Crystell Guadalupe Guzman-Priego

Alma Genis

Sherezada Pool Garcia

Maria Lilia Lopez-Narvaez

Jose Manuel Rodriguez-Perez

Affiliations

Soon will be listed here.

Abstract

Background: The aim of this case-control study was to explore the association by gender between the gene variants and suicidal behavior in a Mexican population.

Subjects And Methods: A total of 183 suicide attempters and 208 healthy volunteers were included in this study. We genotyped five polymorphisms of HTR2C (rs547536, rs2192372, rs4272555, rs6318, and rs2428707), then measured the association by genotype, allele, and haplotype.

Results: In the female group, we found an association between two polymorphisms of the HTR2C (rs4272555 and rs2428707) and suicide attempts. The C allele of the single-nucleotide polymorphism (SNP) rs4272555 was associated with a decreased risk of suicide attempt (=0.01, odds ratio =0.26, 95% confidence interval: 0.09-0.79), whereas the G allele of the SNP rs2428707 was associated with an increased risk of suicide attempt (=0.01, odds ratio =3.68, 95% confidence interval: 1.24-10.90). No significant association was observed between the other polymorphisms studied (rs547536, rs2192372, rs6318) or haplotypes with suicide attempts.

Conclusion: These findings suggest a possible risk factor of the gene in the pathology of suicidal behavior in Mexican population. More studies are necessary to confirm this association.

Citing Articles

Serotonin Receptor Gene Polymorphisms Are Associated with Cerebrospinal Fluid, Genetic, and Neuropsychological Biomarkers of Alzheimer's Disease.

Babic Leko M, Nikolac Perkovic M, Spanic E, Strac D, Pleic N, Vogrinc Z Biomedicines. 2022; 10(12).

PMID: 36551873 PMC: 9775360. DOI: 10.3390/biomedicines10123118.

Gene-level genome-wide association analysis of suicide attempt, a preliminary study in a psychiatric Mexican population.

Gonzalez-Castro T, Martinez-Magana J, Tovilla-Zarate C, Juarez-Rojop I, Sarmiento E, Genis-Mendoza A Mol Genet Genomic Med. 2019; 7(12):e983.

PMID: 31578828 PMC: 6900393. DOI: 10.1002/mgg3.983.

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