Environmental Exposures As a Risk Factor for Fibrolamellar Carcinoma

Overview

Journal Mod Pathol

Specialty Pathology

Date 2017 Mar 4

PMID 28256571

Citations 4

Authors

Rondell P Graham

John R Craig

Long Jin

Andre M Oliveira

John R Bergquist

Mark J Truty

Taofic Mounajjed

Patricia T Greipp

Michael S Torbenson

Affiliations

Soon will be listed here.

Abstract

Fibrolamellar carcinoma was first described in 1956. Subsequent large studies failed to identify cases before 1939 (the start of the World War II). This finding, combined with the presence of aryl hydrocarbon receptors on the tumor cells, have suggested that fibrolamellar carcinomas may be caused by environmental exposures that are new since World War II. To investigate this possibility, the surgical pathology files before 1939 were reviewed for hepatocellular carcinomas resected in young individuals. Two cases of fibrolamellar carcinoma were identified, from 1915 to 1924. The diagnosis of fibrolamellar carcinoma was confirmed at the histologic, ultrastructural and proteomic levels. These two fibrolamellar carcinoma cases clarify a key aspect of fibrolamellar carcinoma biology, reducing the likelihood that these tumors result exclusively from post World War II environmental exposures.

Citing Articles

A Multidisciplinary Approach to the Management of Fibrolamellar Carcinoma: Current Perspectives and Future Prospects.

Polychronidis G, Murtha-Lemekhova A, Fuchs J, Karathanasi E, Hoffmann K Onco Targets Ther. 2022; 15:1095-1103.

PMID: 36212724 PMC: 9541294. DOI: 10.2147/OTT.S296127.

Multiomic analysis of microRNA-mediated regulation reveals a proliferative axis involving miR-10b in fibrolamellar carcinoma.

Francisco A, Kanke M, Massa A, Dinh T, Sritharan R, Vakili K JCI Insight. 2022; 7(11).

PMID: 35482409 PMC: 9220943. DOI: 10.1172/jci.insight.154743.

Comparison of Tissue-Based Molecular Markers in Younger versus Older Patients with Colorectal Neoplasia.

Limburg P, Mahoney D, Ahlquist D, Allawi H, Johnson S, Kaiser M Cancer Epidemiol Biomarkers Prev. 2020; 29(8):1570-1576.

PMID: 32467348 PMC: 10964290. DOI: 10.1158/1055-9965.EPI-19-1598.

fusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma.

Kastenhuber E, Lalazar G, Houlihan S, Tschaharganeh D, Baslan T, Chen C Proc Natl Acad Sci U S A. 2017; 114(50):13076-13084.

PMID: 29162699 PMC: 5740683. DOI: 10.1073/pnas.1716483114.

References

EDMONDSON H, STEINER P . Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer. 1954; 7(3):462-503. DOI: 10.1002/1097-0142(195405)7:3<462::aid-cncr2820070308>3.0.co;2-e. View

Klein W, Molmenti E, Colombani P, Grover D, Schwarz K, Boitnott J . Primary liver carcinoma arising in people younger than 30 years. Am J Clin Pathol. 2005; 124(4):512-8. DOI: 10.1309/TT0R7KAL32228E99. View

Munshaw S, Hwang H, Torbenson M, Quinn J, Hansen K, Astemborski J . Laser captured hepatocytes show association of butyrylcholinesterase gene loss and fibrosis progression in hepatitis C-infected drug users. Hepatology. 2012; 56(2):544-54. PMC: 3388175. DOI: 10.1002/hep.25655. View

Graham R, Terracciano L, Meves A, Vanderboom P, Dasari S, Yeh M . Hepatic adenomas with synchronous or metachronous fibrolamellar carcinomas: both are characterized by LFABP loss. Mod Pathol. 2016; 29(6):607-15. DOI: 10.1038/modpathol.2016.59. View

Morise Z, Morize Z, Sugioka A, Mizoguchi Y, Fujita J, Hoshimoto S . Fibrolamellar carcinoma of the liver in a Japanese hepatitis B virus carrier. J Gastroenterol Hepatol. 2005; 20(7):1136-8. DOI: 10.1111/j.1440-1746.2005.03835.x. View

Honeyman J, Simon E, Robine N, Chiaroni-Clarke R, Darcy D, Lim I . Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma. Science. 2014; 343(6174):1010-4. PMC: 4286414. DOI: 10.1126/science.1249484. View

He L, Tian D, Li P, He X . Mouse models of liver cancer: Progress and recommendations. Oncotarget. 2015; 6(27):23306-22. PMC: 4695120. DOI: 10.18632/oncotarget.4202. View

Mitelman F, Johansson B, Mertens F . The impact of translocations and gene fusions on cancer causation. Nat Rev Cancer. 2007; 7(4):233-45. DOI: 10.1038/nrc2091. View

Kwee H . Fibrolamellar hepatocellular carcinoma. Am Fam Physician. 1989; 40(2):175-7. View

10.

Ward S, Huang J, Tickoo S, Thung S, Ladanyi M, Klimstra D . Fibrolamellar carcinoma of the liver exhibits immunohistochemical evidence of both hepatocyte and bile duct differentiation. Mod Pathol. 2010; 23(9):1180-90. DOI: 10.1038/modpathol.2010.105. View

11.

Masuda T, Oikawa H, SATODATE R, Suzuki K, Sato S, Suzuki A . Bile canaliculi-like lumina in fibrolamellar carcinoma of the liver: a light- and electron-microscopic study and three-dimensional examination of serial sections. Pathol Int. 1997; 47(11):763-8. DOI: 10.1111/j.1440-1827.1997.tb04454.x. View

12.

Fausto N, Campbell J . Mouse models of hepatocellular carcinoma. Semin Liver Dis. 2010; 30(1):87-98. DOI: 10.1055/s-0030-1247135. View

13.

Craig J, Peters R, EDMONDSON H, Omata M . Fibrolamellar carcinoma of the liver: a tumor of adolescents and young adults with distinctive clinico-pathologic features. Cancer. 1980; 46(2):372-9. DOI: 10.1002/1097-0142(19800715)46:2<372::aid-cncr2820460227>3.0.co;2-s. View

14.

Oikawa T, Wauthier E, Dinh T, Selitsky S, Reyna-Neyra A, Carpino G . Model of fibrolamellar hepatocellular carcinomas reveals striking enrichment in cancer stem cells. Nat Commun. 2015; 6:8070. PMC: 4600730. DOI: 10.1038/ncomms9070. View

15.

Graham R, Jin L, Knutson D, Kloft-Nelson S, Greipp P, Waldburger N . DNAJB1-PRKACA is specific for fibrolamellar carcinoma. Mod Pathol. 2015; 28(6):822-9. DOI: 10.1038/modpathol.2015.4. View

16.

Davison F, Fagan E, Portmann B, Williams R . HBV-DNA sequences in tumor and nontumor tissue in a patient with the fibrolamellar variant of hepatocellular carcinoma. Hepatology. 1990; 12(4 Pt 1):676-9. DOI: 10.1002/hep.1840120410. View

17.

Kakar S, Burgart L, Batts K, Garcia J, Jain D, Ferrell L . Clinicopathologic features and survival in fibrolamellar carcinoma: comparison with conventional hepatocellular carcinoma with and without cirrhosis. Mod Pathol. 2005; 18(11):1417-23. DOI: 10.1038/modpathol.3800449. View

18.

Vecchio F, Fabiano A, Ghirlanda G, Manna R, Massi G . Fibrolamellar carcinoma of the liver: the malignant counterpart of focal nodular hyperplasia with oncocytic change. Am J Clin Pathol. 1984; 81(4):521-6. DOI: 10.1093/ajcp/81.4.521. View

19.

Grimwood J, Gordon L, Olsen A, Terry A, Schmutz J, Lamerdin J . The DNA sequence and biology of human chromosome 19. Nature. 2004; 428(6982):529-35. DOI: 10.1038/nature02399. View

20.

Aplan P . Causes of oncogenic chromosomal translocation. Trends Genet. 2005; 22(1):46-55. PMC: 1762911. DOI: 10.1016/j.tig.2005.10.002. View