Insulin and β Adrenergic Receptor Signaling: Crosstalk in Heart

Overview

Journal Trends Endocrinol Metab

Specialty Endocrinology

Date 2017 Mar 4

PMID 28256297

Citations 18

Authors

Qin Fu

Qingtong Wang

Yang K Xiang

Affiliations

Soon will be listed here.

Abstract

Recent advances show that insulin may affect β adrenergic receptor (βAR) signaling in the heart to modulate cardiac function in clinically relevant states, such as diabetes mellitus (DM) and heart failure (HF). Conversely, activation of βAR regulates cardiac glucose uptake and promotes insulin resistance (IR) in HF. Here, we discuss the recent characterization of the interaction between the cardiac insulin receptor (InsR) and βAR in the myocardium, in which insulin stimulation crosstalks with cardiac βAR via InsR substrate (IRS)-dependent and G-protein receptor kinase 2 (GRK2)-mediated phosphorylation of βAR. The insulin-induced phosphorylation promotes βAR coupling to G and expression of phosphodiesterase 4D, which both inhibit cardiac adrenergic signaling and compromise cardiac contractile function. These recent developments could support new approaches for the effective prevention or treatment of obesity- or DM-related HF.

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