High-Sensitivity Troponin As a Biomarker in Heart Rhythm Disease

Overview

Journal Am J Cardiol

Specialty Cardiology & Vascular Diseases

Date 2017 Mar 4

PMID 28256250

Citations 13

Authors

Cian P McCarthy

Omair Yousuf

Alvaro Alonso

Elizabeth Selvin

Hugh Calkins

John W McEvoy

Affiliations

Soon will be listed here.

Abstract

Biomarkers are important prognostic tools in various cardiovascular conditions, including coronary artery disease and heart failure. Although their utility in cardiac electrophysiology (EP) is less established, biomarkers may guide EP clinical practice by identifying patients at risk for developing arrhythmias and their complications, in addition to augmenting therapeutic decisions by targeting appropriate pharmacologic and interventional therapies to patients who may benefit most. In this review, we focus on the prognostic role of high-sensitivity cardiac troponin (hs-cTn) assays-which detect subclinical cardiac myocyte damage-in cardiac arrhythmias and their sequelae. We review the current literature on hs-cTn and its impact on various arrhythmia disease states and also provide suggestions for future research in this field. In conclusion, although the utility of hs-cTn assays remains at an investigational stage in cardiac EP, studies to date have suggested value as a prognostic biomarker in atrial fibrillation and as a screening marker for patients at high risk of sudden cardiac death (both in the general population and among those with hypertrophic cardiomyopathy).

Citing Articles

Association of high-sensitivity cardiac troponin T with territorial middle cerebral artery brain infarctions and dynamic cerebral autoregulation.

Bolognese M, Weichsel L, Osterreich M, Muller M, Karwacki G, Lakatos L J Cent Nerv Syst Dis. 2024; 16:11795735241302725.

PMID: 39600968 PMC: 11590146. DOI: 10.1177/11795735241302725.

High-Sensitivity Cardiac Troponin T and Cardiovascular Risk After Ischemic Stroke or Transient Ischemic Attack.

Willeit K, Boehme C, Toell T, Tschiderer L, Seekircher L, Mayer-Suess L JACC Adv. 2024; 3(7):101022.

PMID: 39130023 PMC: 11312770. DOI: 10.1016/j.jacadv.2024.101022.

Effect of an Intensive Lifestyle Intervention on Circulating Biomarkers of Atrial Fibrillation-Related Pathways among Adults with Metabolic Syndrome: Results from a Randomized Trial.

Li L, Alonso A, Romaguera D, Alonso-Gomez A, Razquin C, Tojal-Sierra L J Clin Med. 2024; 13(7).

PMID: 38610897 PMC: 11012583. DOI: 10.3390/jcm13072132.

Elevated High Sensitivity Cardiac Troponin T is Nonlinearly Associated with Poor Prognosis in Aging COVID-19 Patients: A Retrospective Study.

Jin X, Yang H, Ma W, Yuan Y, Li T Infect Drug Resist. 2023; 16:5155-5163.

PMID: 37581166 PMC: 10423578. DOI: 10.2147/IDR.S422492.

6-year change in high sensitivity cardiac troponin T and the risk of atrial fibrillation in the Atherosclerosis Risk in Communities cohort.

Li L, Selvin E, Hoogeveen R, Soliman E, Chen L, Norby F Clin Cardiol. 2021; 44(11):1594-1601.

PMID: 34545585 PMC: 8571551. DOI: 10.1002/clc.23727.

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