Early Infant Growth Velocity Patterns and Cardiovascular and Metabolic Outcomes in Childhood

Overview

Journal J Pediatr

Specialty Pediatrics

Date 2017 Mar 4

PMID 28256212

Citations 19

Authors

Tamara Marinkovic

Liza Toemen

Claudia J Kruithof

Irwin Reiss

Lennie van Osch-Gevers

Albert Hofman

Oscar H Franco

Vincent W V Jaddoe

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate the impact of infant growth on childhood health by examining the associations of detailed longitudinal infant weight velocity patterns with childhood cardiovascular and metabolic outcomes.

Study Design: In a population-based prospective cohort study of 4649 children, we used repeated growth measurements at age 0-3 years to derive peak weight velocity (PWV), age at adiposity peak (AGEAP), and body mass index at adiposity peak (BMIAP). At age 6 years, we measured blood pressure, left ventricular mass, and cholesterol, triglyceride, and insulin concentrations and defined children with clusters of risk factors. We assessed associations using 2 multivariable linear regression models.

Results: A 1-SDS-higher infant PWV was associated with higher diastolic blood pressure (0.05 SDS; 95% CI, 0.02-0.09) and lower left ventricular mass (-0.05 SDS; 95% CI, -0.09 to -0.01), independent of body size. A 1-SDS-higher BMIAP was associated with higher systolic (0.12; 95% CI, 0.09-0.16) and diastolic (0.05; 95% CI, 0.01-0.08) blood pressure, but these associations were explained by childhood BMI. We did not observe any associations of PWV, BMIAP, and AGEAP with cholesterol and insulin concentrations. Higher PWV and AGEAP were associated with elevated risk of clustering of cardiovascular risk factors in childhood (P < .05).

Conclusion: Infant weight velocity patterns are associated with cardiovascular outcomes. Further studies are needed to explore the associations with metabolic outcomes and long-term consequences.

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References

Ekelund U, Ong K, Linne Y, Neovius M, Brage S, Dunger D . Association of weight gain in infancy and early childhood with metabolic risk in young adults. J Clin Endocrinol Metab. 2006; 92(1):98-103. DOI: 10.1210/jc.2006-1071. View

Schiller N, Shah P, Crawford M, DeMaria A, Devereux R, FEIGENBAUM H . Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr. 1989; 2(5):358-67. DOI: 10.1016/s0894-7317(89)80014-8. View

Hancox R, Landhuis C . Correlation between measures of insulin resistance in fasting and non-fasting blood. Diabetol Metab Syndr. 2011; 3(1):23. PMC: 3177770. DOI: 10.1186/1758-5996-3-23. View

Berkey C, Reed R . A model for describing normal and abnormal growth in early childhood. Hum Biol. 1987; 59(6):973-87. View

Fabricius-Bjerre S, Jensen R, Faerch K, Larsen T, Molgaard C, Michaelsen K . Impact of birth weight and early infant weight gain on insulin resistance and associated cardiovascular risk factors in adolescence. PLoS One. 2011; 6(6):e20595. PMC: 3107215. DOI: 10.1371/journal.pone.0020595. View

Tzoulaki I, Sovio U, Pillas D, Hartikainen A, Pouta A, Laitinen J . Relation of immediate postnatal growth with obesity and related metabolic risk factors in adulthood: the northern Finland birth cohort 1966 study. Am J Epidemiol. 2010; 171(9):989-98. DOI: 10.1093/aje/kwq027. View

Crispi F, Bijnens B, Figueras F, Bartrons J, Eixarch E, le Noble F . Fetal growth restriction results in remodeled and less efficient hearts in children. Circulation. 2010; 121(22):2427-36. DOI: 10.1161/CIRCULATIONAHA.110.937995. View

Kajantie E, Barker D, Osmond C, Forsen T, Eriksson J . Growth before 2 years of age and serum lipids 60 years later: the Helsinki Birth Cohort study. Int J Epidemiol. 2008; 37(2):280-9. DOI: 10.1093/ije/dyn012. View

Vijayakumar M, Fall C, Osmond C, Barker D . Birth weight, weight at one year, and left ventricular mass in adult life. Br Heart J. 1995; 73(4):363-7. PMC: 483831. DOI: 10.1136/hrt.73.4.363. View

10.

Fagerberg B, Bondjers L, Nilsson P . Low birth weight in combination with catch-up growth predicts the occurrence of the metabolic syndrome in men at late middle age: the Atherosclerosis and Insulin Resistance study. J Intern Med. 2004; 256(3):254-9. DOI: 10.1111/j.1365-2796.2004.01361.x. View

11.

Jaddoe V, de Jonge L, Hofman A, Franco O, Steegers E, Gaillard R . First trimester fetal growth restriction and cardiovascular risk factors in school age children: population based cohort study. BMJ. 2014; 348:g14. PMC: 3901421. DOI: 10.1136/bmj.g14. View

12.

Cantinotti M, Scalese M, Murzi B, Assanta N, Spadoni I, De Lucia V . Echocardiographic nomograms for chamber diameters and areas in Caucasian children. J Am Soc Echocardiogr. 2014; 27(12):1279-92.e2. DOI: 10.1016/j.echo.2014.08.005. View

13.

Skilton M, Marks G, Ayer J, Garden F, Garnett S, Harmer J . Weight gain in infancy and vascular risk factors in later childhood. Pediatrics. 2013; 131(6):e1821-8. DOI: 10.1542/peds.2012-2789. View

14.

Kaul S, Rothney M, Peters D, Wacker W, Davis C, Shapiro M . Dual-energy X-ray absorptiometry for quantification of visceral fat. Obesity (Silver Spring). 2012; 20(6):1313-8. PMC: 3361068. DOI: 10.1038/oby.2011.393. View

15.

Hof M, Vrijkotte T, de Hoog M, van Eijsden M, Zwinderman A . Association between infancy BMI peak and body composition and blood pressure at age 5-6 years. PLoS One. 2013; 8(12):e80517. PMC: 3851737. DOI: 10.1371/journal.pone.0080517. View

16.

Kruithof C, Gishti O, Hofman A, Gaillard R, Jaddoe V . Infant weight growth velocity patterns and general and abdominal adiposity in school-age children. The Generation R Study. Eur J Clin Nutr. 2016; 70(10):1144-1150. PMC: 5427180. DOI: 10.1038/ejcn.2016.60. View

17.

Jaddoe V, Van Duijn C, Franco O, van der Heijden A, van Iizendoorn M, de Jongste J . The Generation R Study: design and cohort update 2012. Eur J Epidemiol. 2012; 27(9):739-56. DOI: 10.1007/s10654-012-9735-1. View

18.

Toemen L, de Jonge L, Gishti O, Osch-Gevers L, Taal H, Steegers E . Longitudinal growth during fetal life and infancy and cardiovascular outcomes at school-age. J Hypertens. 2016; 34(7):1396-406. DOI: 10.1097/HJH.0000000000000947. View

19.

Law C, Shiell A, Newsome C, Syddall H, Shinebourne E, Fayers P . Fetal, infant, and childhood growth and adult blood pressure: a longitudinal study from birth to 22 years of age. Circulation. 2002; 105(9):1088-92. DOI: 10.1161/hc0902.104677. View

20.

Barker D, Martyn C, Osmond C, Hales C, Fall C . Growth in utero and serum cholesterol concentrations in adult life. BMJ. 1993; 307(6918):1524-7. PMC: 1679540. DOI: 10.1136/bmj.307.6918.1524. View