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Biology and Pharmacology of Recombinant Human Interleukin-1 Beta-induced Rat Ear Inflammation

Overview
Journal Agents Actions
Specialty Pharmacology
Date 1987 Aug 1
PMID 2825480
Citations 5
Authors
L M De Young
D A Spires
J Kheifets
T G Terrell
Affiliations
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Abstract

A single, 10 ng intradermal injection of human recombinant interleukin-1 beta (rIL-1 beta) into rat ears produced acute inflammation. Tissue wet weight (edema) and total myeloperoxidase activity (PMN accumulation), peaked at 3 hours and returned to base line at 3 days. Given orally, 1 hour prior to rIL-1 beta injection, cyproheptadine, dexamethasone, conventional NSAID's, or mixed cyclooxygenase/lipoxygenase inhibitors were potent antagonists of edema and moderate antagonists of PMN accumulation. In addition, the putative DMARD's, auranofin, dapsone, and levamisole were effective inhibitors of rIL-1 beta induced inflammation.

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