Cellular Factories for Coenzyme Q Production

Overview

Journal Microb Cell Fact

Publisher Biomed Central

Specialties Biotechnology
Microbiology

Date 2017 Mar 4

PMID 28253886

Citations 25

Authors

Sean Qiu En Lee

Tsu Soo Tan

Makoto Kawamukai

Ee Sin Chen

Affiliations

Soon will be listed here.

Abstract

Coenzyme Q (CoQ), a benzoquinone present in most organisms, plays an important role in the electron-transport chain, and its deficiency is associated with various neuropathies and muscular disorders. CoQ is the only lipid-soluble antioxidant found in humans, and for this, it is gaining popularity in the cosmetic and healthcare industries. To meet the growing demand for CoQ, there has been considerable interest in ways to enhance its production, the most effective of which remains microbial fermentation. Previous attempts to increase CoQ production to an industrial scale have thus far conformed to the strategies used in typical metabolic engineering endeavors. However, the emergence of new tools in the expanding field of synthetic biology has provided a suite of possibilities that extend beyond the traditional modes of metabolic engineering. In this review, we cover the various strategies currently undertaken to upscale CoQ production, and discuss some of the potential novel areas for future research.

Citing Articles

Precise regulating the specific oxygen consumption rate to strengthen the CoQ biosynthesis by Rhodobater sphaeroides.

Li B, Ge Y, Liang J, Zhu Z, Chen B, Li D Bioresour Bioprocess. 2024; 11(1):106.

PMID: 39496909 PMC: 11534906. DOI: 10.1186/s40643-024-00813-0.

Cancer cell stiffening via CoQ and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer.

Tosi G, Paoli A, Zuccolotto G, Turco E, Simonato M, Tosoni D Nat Commun. 2024; 15(1):8214.

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Changes in lipids and medium- and long-chain fatty acids during the spontaneous fermentation of ripened pu-erh tea.

Chen Q, Liu M, Li R, Jiang B, Liu K, Xiao Y Curr Res Food Sci. 2024; 9:100831.

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High-yield porphyrin production through metabolic engineering and biocatalysis.

Chen H, Wang Y, Wang W, Cao T, Zhang L, Wang Z Nat Biotechnol. 2024; .

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Coenzyme Q10: A Key Antioxidant in the Management of Diabetes-Induced Cardiovascular Complications-An Overview of Mechanisms and Clinical Evidence.

Samimi F, Namiranian N, Sharifi-Rigi A, Siri M, Abazari O, Dastghaib S Int J Endocrinol. 2024; 2024:2247748.

PMID: 38524871 PMC: 10959587. DOI: 10.1155/2024/2247748.

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