» Articles » PMID: 28249920

Additional Prognostic Value of Lymph Node Ratio (LNR) and Number of Negative Lymph Nodes (NLNs) in Chinese Patients with Triple Negative Breast Cancer

Overview
Specialty Biochemistry
Date 2017 Mar 3
PMID 28249920
Citations 8
Authors
Affiliations
Soon will be listed here.
Abstract

Objective: This study aimed to investigate the prognostic value of lymph node ratio (LNR), number of removed lymph nodes (RLNs), and number of negative lymph nodes (NLNs) in Chinese patients with triple negative breast cancer.

Methods: The study cohort comprised 394 breast cancer patients with the triple negative subtype. The log-rank test and Cox proportional hazards analysis was employed to identify prognostic clinicopathological factors.

Results: The median follow-up time was 61 months, and the five-year disease-free survival (DFS) and overall survival (OS) were 63.75% and 64.97%, respectively. Univariate Cox survival analysis revealed that pN stage, LNR, and NLNs were significant prognostic factors for DFS and OS (all, <0.05). Multivariate analysis including pN stage and LNR showed that LNR was an independent prognostic factor for DFS (=0.047) and OS (=0.0497). When combining pN stage, LNR, and NLNs together, only NLNs was an independent prognostic factor for DFS and OS (=0.014). LNR is prognostically superior to pN stage in patients with triple negative breast cancer.

Conclusions: Our study revealed that LNR and NLNs can provide additional prognostic value for DFS and OS. Moreover, LNR had a better prognostic value compared with pN stage.

Citing Articles

Clinical Association of Negative Lymph Nodes With Adjuvant Chemotherapy in Patients With T3N0 Rectal Cancer.

Lei D, Liu Z, Kang X, Zeng Z, Xie H, Cai T Gastroenterol Res Pract. 2025; 2025:3241615.

PMID: 40007592 PMC: 11858705. DOI: 10.1155/grp/3241615.


Nomograms to predict the long-term prognosis for non-metastatic invasive lobular breast carcinoma: a population-based study.

Guan Y, Huang S, Yu B Sci Rep. 2024; 14(1):19477.

PMID: 39174612 PMC: 11341842. DOI: 10.1038/s41598-024-68931-5.


Tumor-derived exosomal miR-148b-3p mediates M2 macrophage polarization via TSC2/mTORC1 to promote breast cancer migration and invasion.

Hao C, Sheng Z, Wang W, Feng R, Zheng Y, Xiao Q Thorac Cancer. 2023; 14(16):1477-1491.

PMID: 37144254 PMC: 10234784. DOI: 10.1111/1759-7714.14891.


Survival Nomogram for Young Breast Cancer Patients Based on the SEER Database and an External Validation Cohort.

Huang X, Luo Z, Liang W, Xie G, Lang X, Gou J Ann Surg Oncol. 2022; 29(9):5772-5781.

PMID: 35661275 PMC: 9356966. DOI: 10.1245/s10434-022-11911-8.


Breast Cancer Patients With Positive Apical or Infraclavicular/Ipsilateral Supraclavicular Lymph Nodes Should Be Excluded in the Application of the Lymph Node Ratio System.

Wang Z, Chong W, Zhang H, Liu X, Zhao Y, Guo Z Front Cell Dev Biol. 2022; 10:784920.

PMID: 35445014 PMC: 9013846. DOI: 10.3389/fcell.2022.784920.