Production of Complement Components by Cells of the Immune System
Overview
Authors
Affiliations
The complement system is an important part of the innate immune defence. It contributes not only to local inflammation, removal and killing of pathogens, but it also assists in shaping of the adaptive immune response. Besides a role in inflammation, complement is also involved in physiological processes such as waste disposal and developmental programmes. The complement system comprises several soluble and membrane-bound proteins. The bulk of the soluble proteins is produced mainly by the liver. While several complement proteins are produced by a wide variety of cell types, other complement proteins are produced by only a few related cell types. As these data suggest that local production by specific cell types may have specific functions, more detailed studies have been employed recently analysing the local and even intracellular role of these complement proteins. Here we review the current knowledge about extrahepatic production and/or secretion of complement components. More specifically, we address what is known about complement synthesis by cells of the human immune system.
Factor B as a therapeutic target for the treatment of complement-mediated diseases.
Kavanagh D, Barratt J, Schubart A, Webb N, Meier M, Fakhouri F Front Immunol. 2025; 16:1537974.
PMID: 40028332 PMC: 11868072. DOI: 10.3389/fimmu.2025.1537974.
Inherent immunity and adaptive immunity: Mechanism and role in AECOPD.
Wu L, Zhang E, Tu Y, Chen Y, Wang C, Ren Y Innate Immun. 2025; 31:17534259251322612.
PMID: 40017227 PMC: 11869301. DOI: 10.1177/17534259251322612.
Candidiasis: Insights into Virulence Factors, Complement Evasion and Antifungal Drug Resistance.
Gaffar N, Valand N, Venkatraman Girija U Microorganisms. 2025; 13(2).
PMID: 40005639 PMC: 11858274. DOI: 10.3390/microorganisms13020272.
The role of complement in tumor immune tolerance and drug resistance: a double-edged sword.
Yang R, Fu D, Liao A Front Immunol. 2025; 16:1529184.
PMID: 39958348 PMC: 11825488. DOI: 10.3389/fimmu.2025.1529184.
Contreras M, Rafael M, Sobrino I, Almazan C, Pastor Comin J, Valdes J PLoS One. 2025; 20(2):e0318439.
PMID: 39928697 PMC: 11809815. DOI: 10.1371/journal.pone.0318439.