Plasticity in the Lung: Making and Breaking Cell Identity

Overview

Journal Development

Specialty Biology

Date 2017 Mar 2

PMID 28246210

Citations 97

Authors

Purushothama Rao Tata

Jayaraj Rajagopal

Affiliations

Soon will be listed here.

Abstract

In contrast to a prior emphasis on the finality of cell fate decisions in developmental systems, cellular plasticity is now emerging as a general theme in the biology of multiple adult organ systems. In the lung, lineage tracing has been used to identify distinct epithelial stem and progenitor cell populations. These cells, together with their differentiated progeny, maintain a stable identity during steady state conditions, but can display remarkable lineage plasticity following injury. This Review summarizes our current understanding of the different cell lineages of the adult mammalian lung and their responses to injury. In the lung, which is constantly exposed to infection and aerosolized toxins, epithelial plasticity might be more of a rule than an exception, and it is likely that different injuries elicit different facultative responses.

Citing Articles

Preclinical Models for Functional Precision Lung Cancer Research.

Yu J, Kiss Z, Ma W, Liang R, Li T Cancers (Basel). 2025; 17(1.

PMID: 39796653 PMC: 11718887. DOI: 10.3390/cancers17010022.

Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy.

Witten J, Raji I, Manan R, Beyer E, Bartlett S, Tang Y Nat Biotechnol. 2024; .

PMID: 39658727 DOI: 10.1038/s41587-024-02490-y.

Comprehensive analysis of single-cell RNA and bulk RNA sequencing based on M2 tumor-associated macrophage and angiogenesis-related genes to assess prognosis and therapeutic response in lung adenocarcinoma.

Liu A, Liu G, Wang X, Yan D, Zhang J, Wei L Heliyon. 2024; 10(14):e34784.

PMID: 39148979 PMC: 11325380. DOI: 10.1016/j.heliyon.2024.e34784.

Origins of cancer: ain't it just mature cells misbehaving?.

Cho C, Brown J, Mills J EMBO J. 2024; 43(13):2530-2551.

PMID: 38773319 PMC: 11217308. DOI: 10.1038/s44318-024-00099-0.

Differences in the anatomy and physiology of the human and rat respiratory tracts and impact on toxicological assessments.

Stucki A, Sauer U, Allen D, Kleinstreuer N, Perron M, Yozzo K Regul Toxicol Pharmacol. 2024; 150:105648.

PMID: 38772524 PMC: 11198871. DOI: 10.1016/j.yrtph.2024.105648.

References

Matalon S, Maull E . Understanding and treating chlorine-induced lung injury. Proc Am Thorac Soc. 2010; 7(4):253. DOI: 10.1513/pats.7.4.253. View

Stripp B . Hierarchical organization of lung progenitor cells: is there an adult lung tissue stem cell?. Proc Am Thorac Soc. 2008; 5(6):695-8. PMC: 2645261. DOI: 10.1513/pats.200801-011AW. View

Kumar P, Hu Y, Yamamoto Y, Hoe N, Wei T, Mu D . Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection. Cell. 2011; 147(3):525-38. PMC: 4040224. DOI: 10.1016/j.cell.2011.10.001. View

Yang J, Hernandez B, Martinez Alanis D, Narvaez Del Pilar O, Vila-Ellis L, Akiyama H . The development and plasticity of alveolar type 1 cells. Development. 2015; 143(1):54-65. PMC: 4725210. DOI: 10.1242/dev.130005. View

Blanpain C, Fuchs E . Stem cell plasticity. Plasticity of epithelial stem cells in tissue regeneration. Science. 2014; 344(6189):1242281. PMC: 4523269. DOI: 10.1126/science.1242281. View

Ding B, Nolan D, Guo P, Babazadeh A, Cao Z, Rosenwaks Z . Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization. Cell. 2011; 147(3):539-53. PMC: 3228268. DOI: 10.1016/j.cell.2011.10.003. View

Hegab A, Nickerson D, Ha V, Darmawan D, Gomperts B . Repair and regeneration of tracheal surface epithelium and submucosal glands in a mouse model of hypoxic-ischemic injury. Respirology. 2012; 17(7):1101-13. PMC: 3723929. DOI: 10.1111/j.1440-1843.2012.02204.x. View

Tata P, Rajagopal J . Cellular plasticity: 1712 to the present day. Curr Opin Cell Biol. 2016; 43:46-54. PMC: 5154913. DOI: 10.1016/j.ceb.2016.07.005. View

Liu J, Nettesheim P, Randell S . Growth and differentiation of tracheal epithelial progenitor cells. Am J Physiol. 1994; 266(3 Pt 1):L296-307. DOI: 10.1152/ajplung.1994.266.3.L296. View

10.

Song H, Yao E, Lin C, Gacayan R, Chen M, Chuang P . Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis. Proc Natl Acad Sci U S A. 2012; 109(43):17531-6. PMC: 3491514. DOI: 10.1073/pnas.1207238109. View

11.

Guha A, Vasconcelos M, Zhao R, Gower A, Rajagopal J, Cardoso W . Analysis of Notch signaling-dependent gene expression in developing airways reveals diversity of Clara cells. PLoS One. 2014; 9(2):e88848. PMC: 3931645. DOI: 10.1371/journal.pone.0088848. View

12.

Franks T, Colby T, Travis W, Tuder R, Reynolds H, Brody A . Resident cellular components of the human lung: current knowledge and goals for research on cell phenotyping and function. Proc Am Thorac Soc. 2008; 5(7):763-6. DOI: 10.1513/pats.200803-025HR. View

13.

Reynolds S, Hong K, Giangreco A, Mango G, Guron C, Morimoto Y . Conditional clara cell ablation reveals a self-renewing progenitor function of pulmonary neuroendocrine cells. Am J Physiol Lung Cell Mol Physiol. 2000; 278(6):L1256-63. DOI: 10.1152/ajplung.2000.278.6.L1256. View

14.

Ghosh M, Helm K, Smith R, Giordanengo M, Li B, Shen H . A single cell functions as a tissue-specific stem cell and the in vitro niche-forming cell. Am J Respir Cell Mol Biol. 2010; 45(3):459-69. PMC: 3175586. DOI: 10.1165/rcmb.2010-0314OC. View

15.

Pardo-Saganta A, Tata P, Law B, Saez B, Chow R, Prabhu M . Parent stem cells can serve as niches for their daughter cells. Nature. 2015; 523(7562):597-601. PMC: 4521991. DOI: 10.1038/nature14553. View

16.

Evans M, Cabral L, Stephens R, Freeman G . Transformation of alveolar type 2 cells to type 1 cells following exposure to NO2. Exp Mol Pathol. 1975; 22(1):142-50. DOI: 10.1016/0014-4800(75)90059-3. View

17.

Paul M, Bisht B, Darmawan D, Chiou R, Ha V, Wallace W . Dynamic changes in intracellular ROS levels regulate airway basal stem cell homeostasis through Nrf2-dependent Notch signaling. Cell Stem Cell. 2014; 15(2):199-214. PMC: 4127166. DOI: 10.1016/j.stem.2014.05.009. View

18.

Kim T, Li F, Ferreiro-Neira I, Ho L, Luyten A, Nalapareddy K . Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity. Nature. 2014; 506(7489):511-5. PMC: 4151315. DOI: 10.1038/nature12903. View

19.

Watson J, Rulands S, Wilkinson A, Wuidart A, Ousset M, Van Keymeulen A . Clonal Dynamics Reveal Two Distinct Populations of Basal Cells in Slow-Turnover Airway Epithelium. Cell Rep. 2015; 12(1):90-101. PMC: 4518462. DOI: 10.1016/j.celrep.2015.06.011. View

20.

Hong K, Reynolds S, Giangreco A, Hurley C, Stripp B . Clara cell secretory protein-expressing cells of the airway neuroepithelial body microenvironment include a label-retaining subset and are critical for epithelial renewal after progenitor cell depletion. Am J Respir Cell Mol Biol. 2001; 24(6):671-81. DOI: 10.1165/ajrcmb.24.6.4498. View