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Prognostic Stratification Improvement by Integrating ID1/ID3/IGJ Gene Expression Signature and Immunophenotypic Profile in Adult Patients with B-ALL

Overview
Publisher Biomed Central
Specialty Oncology
Date 2017 Mar 2
PMID 28245840
Citations 7
Authors
Affiliations
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Abstract

Background: Survival of adults with B-Acute Lymphoblastic Leukemia requires accurate risk stratification of patients in order to provide the appropriate therapy. Contemporary techniques, using clinical and cytogenetic variables are incomplete for prognosis prediction.

Methods: To improve the classification of adult patients diagnosed with B-ALL into prognosis groups, two strategies were examined and combined: the expression of the ID1/ID3/IGJ gene signature by RT-PCR and the immunophenotypic profile of 19 markers proposed in the EuroFlow protocol by Flow Cytometry in bone marrow samples.

Results: Both techniques were correlated to stratify patients into prognostic groups. An inverse relationship between survival and expression of the three-genes signature was observed and an immunophenotypic profile associated with clinical outcome was identified. Markers CD10 and CD20 were correlated with simultaneous overexpression of ID1, ID3 and IGJ. Patients with simultaneous expression of the poor prognosis gene signature and overexpression of CD10 or CD20, had worse Event Free Survival and Overall Survival than patients who had either the poor prognosis gene expression signature or only CD20 or CD10 overexpressed.

Conclusion: By utilizing the combined evaluation of these two immunophenotypic markers along with the poor prognosis gene expression signature, the risk stratification can be significantly strengthened. Further studies including a large number of patients are needed to confirm these findings.

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References
1.
Gokbuget N, Hoelzer D, Arnold R, Bohme A, Bartram C, Freund M . Treatment of Adult ALL according to protocols of the German Multicenter Study Group for Adult ALL (GMALL). Hematol Oncol Clin North Am. 2001; 14(6):1307-25, ix. DOI: 10.1016/s0889-8588(05)70188-x. View

2.
Quijano S, Torres M, Vasquez L, Cuellar G, Romero M, Martin E . [Correlation of the t(9;22), t(12;21), and DNA hyperdiploid content with immunophenotype and proliferative rate of leukemic B-cells of pediatric patients with B-cell acute lymphoblastic leukemia]. Biomedica. 2014; 33(3):468-86. DOI: 10.7705/biomedica.v33i3.1441. View

3.
Sharma P, Patel D, Chaudhary J . Id1 and Id3 expression is associated with increasing grade of prostate cancer: Id3 preferentially regulates CDKN1B. Cancer Med. 2013; 1(2):187-97. PMC: 3544440. DOI: 10.1002/cam4.19. View

4.
Lyden D, Young A, Zagzag D, Yan W, Gerald W, OReilly R . Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. Nature. 1999; 401(6754):670-7. DOI: 10.1038/44334. View

5.
Harvey R, Mullighan C, Wang X, Dobbin K, Davidson G, Bedrick E . Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome. Blood. 2010; 116(23):4874-84. PMC: 3321747. DOI: 10.1182/blood-2009-08-239681. View