» Articles » PMID: 28245761

MicroRNAs As Big Regulators of Neural Stem/Progenitor Cell Proliferation, Differentiation and Migration: A Potential Treatment for Stroke

Overview
Journal Curr Pharm Des
Date 2017 Mar 2
PMID 28245761
Citations 12
Authors
Affiliations
Soon will be listed here.
Abstract

Background: Neural stem/progenitor cells (NSPCs)-based treatment is a potential therapeutic approach for stroke. MicroRNAs (miRNAs) have been recently verified as promoters or suppressors in the regulation of NSPCs. However, the underlying mechanisms regulating cell biological behaviors of NSPCs remain largely unknown.

Methods: we retrieved papers focusing on potential roles and mechanisms of miRNAs in the regulation of NSPCs, and paid a special attention to clinical therapeutic potentials of miRNAs in stroke patients. This narrative review provides a comprehensive and critical landscape of this issue.

Results: We summarize the most recent studies on the roles and mechanisms of miRNAs in regulating the proliferation, differentiation and migration of NSPCs and fully discuss the potential clinical implications of miRNAs interacting with NSPCs in stroke patients.

Conclusion: Promising but full of hurdles, miRNAs have been confirmed to play a critical role in regulating NSPCs. Clinical potentials of miRNAs are huge in treating stroke patients receiving NSPCs-based therapy, which can be used as biomarkers for the diagnosis and prognosis, and as targets for controlling the proliferation, differentiation and migration of NSPCs.

Citing Articles

Non-Coding RNAs in Neurological and Neuropsychiatric Disorders: Unraveling the Hidden Players in Disease Pathogenesis.

Ilieva M Cells. 2024; 13(12.

PMID: 38920691 PMC: 11201512. DOI: 10.3390/cells13121063.


Catalpol Alleviates Ischemic Stroke Through Promoting Angiogenesis and Facilitating Proliferation and Differentiation of Neural Stem Cells via the VEGF-A/KDR Pathway.

Sun S, Xu Y, Yu N, Zhang M, Wang J, Wan D Mol Neurobiol. 2023; 60(11):6227-6247.

PMID: 37439957 DOI: 10.1007/s12035-023-03459-9.


MiR-188-5p regulates the proliferation and differentiation of goat skeletal muscle satellite cells by targeting calcium/calmodulin dependent protein kinase II beta.

Jing J, Zhang S, Wei J, Yang Y, Zheng Q, Zhu C Anim Biosci. 2023; 36(12):1775-1784.

PMID: 37402449 PMC: 10623032. DOI: 10.5713/ab.23.0085.


Association of MicroRNAs With Risk of Stroke: A Meta-Analysis.

Deng Y, Huang P, Zhang F, Chen T Front Neurol. 2022; 13:865265.

PMID: 35665049 PMC: 9160310. DOI: 10.3389/fneur.2022.865265.


MiR-101 Protects Against the Cerebral I/R Injury Through Regulating JAK2/STAT3 Signaling Pathway.

Guo X, Shen X, Yong Z Neuropsychiatr Dis Treat. 2021; 17:2791-2802.

PMID: 34465995 PMC: 8403023. DOI: 10.2147/NDT.S292471.