CCAT2: A Novel Oncogenic Long Non-coding RNA in Human Cancers

Overview

Journal Cell Prolif

Date 2017 Mar 1

PMID 28244168

Citations 34

Authors

Yu Xin

Zheng Li

Heyi Zheng

Matthew T V Chan

William Ka Kei Wu

Affiliations

Soon will be listed here.

Abstract

Colon cancer-associated transcript 2 (CCAT2) was originally identified as an oncogenic long non-coding RNA in colorectal cancer. Since its discovery, the oncogenic role of CCAT2 has been increasingly demonstrated in human cancers. In this connection, CCAT2 upregulation is frequently reported and very often associated with tumour progression and poor clinical outcomes. Functionally, knockdown of CCAT2 could induce cancer cell apoptosis and suppress cell proliferation and invasiveness, suggesting that CCAT2 might be a therapeutic target. The present review summarized current literature concerning the expression and functional role of CCAT2 in human malignancies.

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