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Identification of the Structural Gene Encoding the SH-activated Hemolysin of Listeria Monocytogenes: Listeriolysin O is Homologous to Streptolysin O and Pneumolysin

Overview
Journal Infect Immun
Publisher American Society for Microbiology
Specialty Allergy & Immunology
Date 1987 Dec 1
PMID 2824384
Citations 34
Authors
J Mengaud
J Chenevert
C Geoffroy
J L Gaillard
P Cossart
Affiliations
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Abstract

By immunoblotting with an antiserum raised against purified listeriolysin O, we have detected the presence of a truncated protein of 52 kilodaltons in culture supernatants of a Tn1545-induced nonhemolytic mutant of Listeria monocytogenes (J.L. Gaillard, P. Berche, and P. Sansonetti, Infect. Immun. 52:50-55, 1986). The region of insertion of the transposon has been cloned and sequenced. The transposon had inserted in an open reading frame the listeriolysin O gene. The deduced amino acid sequence of this open reading frame revealed that listeriolysin O is homologous to streptolysin O and pneumolysin, although homologies were not detectable at the DNA level.

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