Differentiation of Atypical Parkinson Syndromes

Overview

Journal J Neural Transm (Vienna)

Specialties Neurology
Physiology

Date 2017 Mar 1

PMID 28243754

Citations 19

Authors

Gunter U Hoglinger

Jan Kassubek

Ilona Csoti

Reinhard Ehret

Heinz Herbst

Ingmar Wellach

Jurgen Winkler

Wolfgang H Jost

Affiliations

Soon will be listed here.

Abstract

In distinction to idiopathic Parkinson's disease (PD), the diagnosis of atypical Parkinson syndromes comprises dementia with Lewy bodies (DLB), multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD). We set out to write a state-of-the-art guideline as to which investigations and examinations help to differentiate PD vs. atypical Parkinson syndromes in clinical routine.

Citing Articles

Identification of Cognitive Training for Individuals with Parkinson's Disease: A Systematic Review.

Gattoni M, Gobbo S, Feroldi S, Salvatore A, Navarro J, Sorbi S Brain Sci. 2025; 15(1).

PMID: 39851429 PMC: 11763612. DOI: 10.3390/brainsci15010061.

Missed Insights for Earlier Management of Parkinson's Disease and the Value of Dopamine Transporter (DAT) Scans.

Hafeez M, Eoff E, Wei J, Azhar G Geriatrics (Basel). 2024; 9(5).

PMID: 39451858 PMC: 11507427. DOI: 10.3390/geriatrics9050126.

New Perspectives in Radiological and Radiopharmaceutical Hybrid Imaging in Progressive Supranuclear Palsy: A Systematic Review.

Strobel J, Muller H, Ludolph A, Beer A, Sollmann N, Kassubek J Cells. 2023; 12(24).

PMID: 38132096 PMC: 10742083. DOI: 10.3390/cells12242776.

Significance of clinical symptoms and red flags in early differential diagnosis of Parkinson's disease and atypical Parkinsonian syndromes.

Schroter N, van Eimeren T, Classen J, Levin J, Redecker C, Wolz M J Neural Transm (Vienna). 2023; 130(6):839-846.

PMID: 37046147 PMC: 10199882. DOI: 10.1007/s00702-023-02634-5.

Different MAPT haplotypes influence expression of total MAPT in postmortem brain tissue.

Tauber C, Schwarz S, Rosler T, Arzberger T, Gentleman S, Windl O Acta Neuropathol Commun. 2023; 11(1):40.

PMID: 36906636 PMC: 10008602. DOI: 10.1186/s40478-023-01534-9.

References

Huppertz H, Moller L, Sudmeyer M, Hilker R, Hattingen E, Egger K . Differentiation of neurodegenerative parkinsonian syndromes by volumetric magnetic resonance imaging analysis and support vector machine classification. Mov Disord. 2016; 31(10):1506-1517. DOI: 10.1002/mds.26715. View

Kollensperger M, Geser F, Seppi K, Stampfer-Kountchev M, Sawires M, Scherfler C . Red flags for multiple system atrophy. Mov Disord. 2008; 23(8):1093-9. DOI: 10.1002/mds.21992. View

Jost W, Augustis S . Severity of orthostatic hypotension in the course of Parkinson's disease: no correlation with the duration of the disease. Parkinsonism Relat Disord. 2015; 21(3):314-6. DOI: 10.1016/j.parkreldis.2014.12.016. View

Stamelou M, Hoglinger G . A Review of Treatment Options for Progressive Supranuclear Palsy. CNS Drugs. 2016; 30(7):629-36. DOI: 10.1007/s40263-016-0347-2. View

Korczyn A . Vascular parkinsonism--characteristics, pathogenesis and treatment. Nat Rev Neurol. 2015; 11(6):319-26. DOI: 10.1038/nrneurol.2015.61. View

Rizzo G, Martinelli P, Manners D, Scaglione C, Tonon C, Cortelli P . Diffusion-weighted brain imaging study of patients with clinical diagnosis of corticobasal degeneration, progressive supranuclear palsy and Parkinson's disease. Brain. 2008; 131(Pt 10):2690-700. DOI: 10.1093/brain/awn195. View

Schwarz S, Afzal M, Morgan P, Bajaj N, Gowland P, Auer D . The 'swallow tail' appearance of the healthy nigrosome - a new accurate test of Parkinson's disease: a case-control and retrospective cross-sectional MRI study at 3T. PLoS One. 2014; 9(4):e93814. PMC: 3977922. DOI: 10.1371/journal.pone.0093814. View

Dehay B, Bourdenx M, Gorry P, Przedborski S, Vila M, Hunot S . Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations. Lancet Neurol. 2015; 14(8):855-866. PMC: 5217462. DOI: 10.1016/S1474-4422(15)00006-X. View

Videnovic A, Golombek D . Circadian and sleep disorders in Parkinson's disease. Exp Neurol. 2012; 243:45-56. PMC: 3666169. DOI: 10.1016/j.expneurol.2012.08.018. View

10.

Gilman S, Wenning G, Low P, Brooks D, Mathias C, Trojanowski J . Second consensus statement on the diagnosis of multiple system atrophy. Neurology. 2008; 71(9):670-6. PMC: 2676993. DOI: 10.1212/01.wnl.0000324625.00404.15. View

11.

Gibb W, Lees A . The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. J Neurol Neurosurg Psychiatry. 1988; 51(6):745-52. PMC: 1033142. DOI: 10.1136/jnnp.51.6.745. View

12.

Hoglinger G, Respondek G, Stamelou M, Kurz C, Josephs K, Lang A . Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria. Mov Disord. 2017; 32(6):853-864. PMC: 5516529. DOI: 10.1002/mds.26987. View

13.

Jost W . Urological problems in Parkinson's disease: clinical aspects. J Neural Transm (Vienna). 2012; 120(4):587-91. DOI: 10.1007/s00702-012-0914-8. View

14.

Fanciulli A, Wenning G . Multiple-system atrophy. N Engl J Med. 2015; 372(14):1375-6. DOI: 10.1056/NEJMc1501657. View

15.

Respondek G, Hoglinger G . The phenotypic spectrum of progressive supranuclear palsy. Parkinsonism Relat Disord. 2015; 22 Suppl 1:S34-6. DOI: 10.1016/j.parkreldis.2015.09.041. View

16.

Marshall V, Reininger C, Marquardt M, Patterson J, Hadley D, Oertel W . Parkinson's disease is overdiagnosed clinically at baseline in diagnostically uncertain cases: a 3-year European multicenter study with repeat [123I]FP-CIT SPECT. Mov Disord. 2009; 24(4):500-8. DOI: 10.1002/mds.22108. View

17.

Maass S, Levin J, Hoglinger G . Current Treatment of Multiple System Atrophy. Curr Treat Options Neurol. 2016; 18(12):51. DOI: 10.1007/s11940-016-0435-0. View

18.

Busse K, Heilmann R, Kleinschmidt S, Abu-Mugheisib M, Hoppner J, Wunderlich C . Value of combined midbrain sonography, olfactory and motor function assessment in the differential diagnosis of early Parkinson's disease. J Neurol Neurosurg Psychiatry. 2012; 83(4):441-7. DOI: 10.1136/jnnp-2011-301719. View

19.

Caslake R, Moore J, Gordon J, Harris C, Counsell C . Changes in diagnosis with follow-up in an incident cohort of patients with parkinsonism. J Neurol Neurosurg Psychiatry. 2008; 79(11):1202-7. DOI: 10.1136/jnnp.2008.144501. View

20.

Levin J, Kurz A, Arzberger T, Giese A, Hoglinger G . The Differential Diagnosis and Treatment of Atypical Parkinsonism. Dtsch Arztebl Int. 2016; 113(5):61-9. PMC: 4782269. DOI: 10.3238/arztebl.2016.0061. View