Overexpression of ANLN Contributed to Poor Prognosis of Anthracycline-based Chemotherapy in Breast Cancer Patients

Overview

Journal Cancer Chemother Pharmacol

Specialty Oncology

Date 2017 Mar 1

PMID 28243684

Citations 30

Authors

Zhan Wang

Juan Chen

Mei-zuo Zhong

Juan Huang

Yuan-Ping Hu

De-Yun Feng

Zhi-Jiao Zhou

Xiao Luo

Zhao-Qian Liu

Wu-Zhong Jiang

Wei-Bing Zhou

Affiliations

Soon will be listed here.

Abstract

Purpose: To investigate the associations of ANLN expression with prognosis of breast cancer and clinical outcome of anthracycline-based chemotherapy.

Methods: This study enrolled 308 breast cancer patients in which 264 of them received anthracycline-based chemotherapy. Immunohistochemistry was used to detect ANLN expression level of the patients. Clinical characteristics of the patients were collected, and associations of ANLN expression with prognosis were analyzed.

Results: Our results showed that ANLN expression was associated with survival of breast cancer patients, and it was also related to clinical outcome of patients received anthracycline-based chemotherapy. Breast cancer patients with high expression of ANLN would have poor prognosis and poor clinical outcome to anthracycline-based chemotherapy.

Conclusion: ANLN could be an independent prognosis predictor for breast cancer, and its expression might be used to predict the anthracycline-based chemotherapy clinical outcome in breast cancer patients.

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