Why Do We Still Have Helicobacter Pylori in Our Stomachs

Overview

Journal Malays J Med Sci

Specialty General Medicine

Date 2017 Feb 28

PMID 28239271

Citations 19

Authors

Amin Talebi Bezmin Abadi

Enzo Ierardi

Yeong Yeh Lee

Affiliations

Soon will be listed here.

Abstract

The existence of any infectious agent in a highly acidic human stomach is contentious, but the chance finding of is by no means an accident. Once colonises the gastric mucosa, it can persist for a lifetime, and it is intriguing why our immune system is able to tolerate its existence. Some conditions favour the persistence of in the stomach, but other conditions oppose the colonisation of this bacterium. Populations with high and extremely low prevalence of provide useful insights on the clinical outcomes that are associated with this type of infection. Adverse clinical outcomes including peptic ulcer disease and gastric cancer depend on a delicate balance between a harmless inflammation and a more severe kind of inflammation. Is the only good really a dead ? The jury is still out.

Citing Articles

Global trends of cancer: The role of diet, lifestyle, and environmental factors.

Bahrami H, Tafrihi M Cancer Innov. 2023; 2(4):290-301.

PMID: 38089751 PMC: 10686168. DOI: 10.1002/cai2.76.

Frequency and risk factors of H. pylori infection among dental students: an observational cross-sectional study.

Mikhail C, Abd El Maksoud Mohamed A, Shaker O, Desouky E, Shalaby R Sci Rep. 2023; 13(1):14264.

PMID: 37653065 PMC: 10471685. DOI: 10.1038/s41598-023-41246-7.

Prevalence of Helicobacter pylori genotypes: cagA, vacA (m1), vacA (s1), babA2, dupA, iceA1, oipA and their association with gastrointestinal diseases. A cross-sectional study in Quito-Ecuador.

Bustos-Fraga S, Salinas-Pinta M, Vicuna-Almeida Y, de Oliveira R, Baldeon-Rojas L BMC Gastroenterol. 2023; 23(1):197.

PMID: 37280541 PMC: 10246408. DOI: 10.1186/s12876-023-02838-9.

Potential contribution of Helicobacter pylori proteins in the pathogenesis of type 1 gastric neuroendocrine tumor and urticaria. In silico approach.

Sanchez Caraballo A, Guzman Y, Sanchez J, Munera M, Garcia E, Gonzalez-Devia D PLoS One. 2023; 18(4):e0281485.

PMID: 37098080 PMC: 10128923. DOI: 10.1371/journal.pone.0281485.

Cancer-associated fibroblast related gene signature in Helicobacter pylori-based subtypes of gastric carcinoma for prognosis and tumor microenvironment estimation analysis.

Xu R, Yang L, Zhang Z, Liao Y, Yu Y, Zhou D Front Med (Lausanne). 2023; 10:1079470.

PMID: 36744128 PMC: 9889637. DOI: 10.3389/fmed.2023.1079470.

References

Troost E, Hold G, Smith M, Chow W, Rabkin C, McColl K . The role of interleukin-1beta and other potential genetic markers as indicators of gastric cancer risk. Can J Gastroenterol. 2003; 17 Suppl B:8B-12B. DOI: 10.1155/2003/397060. View

Talebi Bezmin Abadi A, Taghvaei T, Wolfram L, Kusters J . Infection with Helicobacter pylori strains lacking dupA is associated with an increased risk of gastric ulcer and gastric cancer development. J Med Microbiol. 2011; 61(Pt 1):23-30. DOI: 10.1099/jmm.0.027052-0. View

Abadi A, Taghvaei T, Ghasemzadeh A, Mobarez A . High frequency of A2143G mutation in clarithromycin-resistant Helicobacter pylori isolates recovered from dyspeptic patients in Iran. Saudi J Gastroenterol. 2011; 17(6):396-9. PMC: 3221114. DOI: 10.4103/1319-3767.87181. View

Talebi Bezmin Abadi A . Therapy of Helicobacter pylori: present medley and future prospective. Biomed Res Int. 2014; 2014:124607. PMC: 3988734. DOI: 10.1155/2014/124607. View

Lee Y, Noridah N, Syed Hassan S, Menon J . Absence of Helicobacter pylori is not protective against peptic ulcer bleeding in elderly on offending agents: lessons from an exceptionally low prevalence population. PeerJ. 2014; 2:e257. PMC: 3932736. DOI: 10.7717/peerj.257. View

Lee Y, Derakhshan M . Environmental and lifestyle risk factors of gastric cancer. Arch Iran Med. 2013; 16(6):358-65. DOI: 013166/AIM.0010. View

Alsahli M, Michetti P . Lactobacilli for the management of Helicobacter pylori. Nutrition. 2001; 17(3):268-9. DOI: 10.1016/s0899-9007(00)00475-5. View

Lee Y, Ismail A, Mustaffa N, Musa K, Abdul Majid N, Choo K . Sociocultural and dietary practices among Malay subjects in the north-eastern region of Peninsular Malaysia: a region of low prevalence of Helicobacter pylori infection. Helicobacter. 2012; 17(1):54-61. DOI: 10.1111/j.1523-5378.2011.00917.x. View

Voss B, Gaddy J, McDonald W, Cover T . Analysis of surface-exposed outer membrane proteins in Helicobacter pylori. J Bacteriol. 2014; 196(13):2455-71. PMC: 4054173. DOI: 10.1128/JB.01768-14. View

10.

Alfizah H, Ramelah M, Rizal A, Anwar A, Isa M . Association of Malaysian Helicobacter pylori virulence polymorphisms with severity of gastritis and patients' ethnicity. Helicobacter. 2012; 17(5):340-9. DOI: 10.1111/j.1523-5378.2012.00956.x. View

11.

Maran S, Lee Y, Xu S, Rajab N, Hasan N, Syed Abdul Aziz S . Gastric precancerous lesions are associated with gene variants in Helicobacter pylori-susceptible ethnic Malays. World J Gastroenterol. 2013; 19(23):3615-22. PMC: 3691040. DOI: 10.3748/wjg.v19.i23.3615. View

12.

Aihara E, Closson C, Matthis A, Schumacher M, Engevik A, Zavros Y . Motility and chemotaxis mediate the preferential colonization of gastric injury sites by Helicobacter pylori. PLoS Pathog. 2014; 10(7):e1004275. PMC: 4102597. DOI: 10.1371/journal.ppat.1004275. View

13.

Covacci A, Telford J, Del Giudice G, Parsonnet J, Rappuoli R . Helicobacter pylori virulence and genetic geography. Science. 1999; 284(5418):1328-33. DOI: 10.1126/science.284.5418.1328. View

14.

Goodwin C, Worsley B . Microbiology of Helicobacter pylori. Gastroenterol Clin North Am. 1993; 22(1):5-19. View

15.

Lee Y, Raj S, Graham D . Helicobacter pylori infection--a boon or a bane: lessons from studies in a low-prevalence population. Helicobacter. 2013; 18(5):338-46. PMC: 3974589. DOI: 10.1111/hel.12058. View

16.

Zhang X, Zhang J, Lin Y, Xu K, Li N, Chen H . Analysis of the relationship between invasive capability of Helicobacter pylori and gastroduodenal diseases. J Med Microbiol. 2015; 64(Pt 5):498-506. DOI: 10.1099/jmm.0.000049. View

17.

Kusters J, Van Vliet A, Kuipers E . Pathogenesis of Helicobacter pylori infection. Clin Microbiol Rev. 2006; 19(3):449-90. PMC: 1539101. DOI: 10.1128/CMR.00054-05. View

18.

Maran S, Lee Y, Xu S, Raj M, Abdul Majid N, Choo K . Towards understanding the low prevalence of Helicobacter pylori in Malays: genetic variants among Helicobacter pylori-negative ethnic Malays in the north-eastern region of Peninsular Malaysia and Han Chinese and South Indians. J Dig Dis. 2012; 14(4):196-202. DOI: 10.1111/1751-2980.12023. View

19.

Talebi Bezmin Abadi A, Rafiei A, Ajami A, Hosseini V, Taghvaei T, Jones K . Helicobacter pylori homB, but not cagA, is associated with gastric cancer in Iran. J Clin Microbiol. 2011; 49(9):3191-7. PMC: 3165595. DOI: 10.1128/JCM.00947-11. View

20.

Cheng A, Li M, Kang W, Cheng V, Chou J, Lau S . Helicobacter pylori causes epigenetic dysregulation of FOXD3 to promote gastric carcinogenesis. Gastroenterology. 2012; 144(1):122-133.e9. DOI: 10.1053/j.gastro.2012.10.002. View