MAGUKs: Multifaceted Synaptic Organizers

Overview

Journal Curr Opin Neurobiol

Specialties Biology
Neurology

Date 2017 Feb 26

PMID 28236779

Citations 77

Authors

Sehoon Won

Jon M Levy

Roger A Nicoll

Katherine W Roche

Affiliations

Soon will be listed here.

Abstract

The PSD-95 family of proteins, known as MAGUKs, have long been recognized to be central building blocks of the PSD. They are categorized as scaffolding proteins, which link surface-expressed receptors to the intracellular signaling molecules. Although the four members of the PSD-95 family (PSD-95, PSD-93, SAP102, and SAP97) have many shared roles in regulating synaptic function, recent studies have begun to delineate specific binding partners and roles in plasticity. In the current review, we will highlight the conserved and unique roles of these proteins.

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