MRI-visible Perivascular Spaces in Cerebral Amyloid Angiopathy and Hypertensive Arteriopathy

Overview

Journal Neurology

Specialty Neurology

Date 2017 Feb 24

PMID 28228568

Citations 152

Authors

Andreas Charidimou

Gregoire Boulouis

Marco Pasi

Eitan Auriel

Ellis S van Etten

Kellen Haley

Alison Ayres

Kristin M Schwab

Sergi Martinez-Ramirez

Joshua N Goldstein

Jonathan Rosand

Anand Viswanathan

Steven M Greenberg

M Edip Gurol

Affiliations

Soon will be listed here.

Abstract

Objective: To assess MRI-visible enlarged perivascular spaces (EPVS) burden and different topographical patterns (in the centrum semiovale [CSO] and basal ganglia [BG]) in 2 common microangiopathies: cerebral amyloid angiopathy (CAA) and hypertensive arteriopathy (HA).

Methods: Consecutive patients with spontaneous intracerebral hemorrhage (ICH) from a prospective MRI cohort were included. Small vessel disease MRI markers, including cerebral microbleeds (CMBs), cortical superficial siderosis (cSS), and white matter hyperintensities (WMH), were rated. CSO-EPVS/BG-EPVS were assessed on a validated 4-point visual rating scale (0 = no EPVS, 1 = <10, 2 = 11-20, 3 = 21-40, and 4 = >40 EPVS). We tested associations of predefined high-degree (score >2) CSO-EPVS and BG-EPVS with other MRI markers in multivariable logistic regression. We subsequently evaluated associations with CSO-EPVS predominance (i.e., CSO-EPVS > BG-EPVS) and BG-EPVS predominance pattern (i.e., BG-EPVS > CSO-EPVS) in adjusted multinomial logistic regression (reference group, BG-EPVS = CSO-EPVS).

Results: We included 315 patients with CAA-ICH and 137 with HA-ICH. High-degree CSO-EPVS prevalence was greater in CAA-related ICH vs HA-related ICH (43.8% vs 17.5%, < 0.001). In multivariable logistic regression, high-degree CSO-EPVS was associated with lobar CMB (odds ratio [OR] 1.33, 95% confidence interval [CI] 1.10-1.61, = 0.003) and cSS (OR 2.08, 95% CI 1.30-3.32, = 0.002). Deep CMBs (OR 2.85, 95% CI 1.75-4.64, < 0.0001) and higher WMH volume (OR 1.02, 95% CI 1.01-1.04, = 0.010) were predictors of high-degree BG-EPVS. A CSO-EPVS-predominant pattern was more common in CAA-ICH than in HA-ICH (75.9% vs 39.4%, respectively, < 0.0001). CSO-PVS predominance was associated with lobar CMB burden and cSS, while BG-EPVS predominance was associated with HA-ICH and WMH volumes.

Conclusions: Different patterns of MRI-visible EPVS provide insights into the dominant underlying microangiopathy type in patients with spontaneous ICH.

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