Fibrinogen and Fibrin in Hemostasis and Thrombosis

Overview

Journal Arterioscler Thromb Vasc Biol

Date 2017 Feb 24

PMID 28228446

Citations 149

Authors

Sravya Kattula

James R Byrnes

Alisa S Wolberg

Affiliations

Soon will be listed here.

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References

Wolberg A, Monroe D, Roberts H, Hoffman M . Elevated prothrombin results in clots with an altered fiber structure: a possible mechanism of the increased thrombotic risk. Blood. 2002; 101(8):3008-13. DOI: 10.1182/blood-2002-08-2527. View

Fickenscher K, Aab A, Stuber W . A photometric assay for blood coagulation factor XIII. Thromb Haemost. 1991; 65(5):535-40. View

Spraggon G, Everse S, Doolittle R . Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin. Nature. 1997; 389(6650):455-62. DOI: 10.1038/38947. View

Yang Z, Mochalkin I, Doolittle R . A model of fibrin formation based on crystal structures of fibrinogen and fibrin fragments complexed with synthetic peptides. Proc Natl Acad Sci U S A. 2000; 97(26):14156-61. PMC: 18887. DOI: 10.1073/pnas.97.26.14156. View

Machlus K, Cardenas J, Church F, Wolberg A . Causal relationship between hyperfibrinogenemia, thrombosis, and resistance to thrombolysis in mice. Blood. 2011; 117(18):4953-63. PMC: 3100702. DOI: 10.1182/blood-2010-11-316885. View

Weisel J . Structure of fibrin: impact on clot stability. J Thromb Haemost. 2007; 5 Suppl 1:116-24. DOI: 10.1111/j.1538-7836.2007.02504.x. View

Mannila M, Lovely R, Kazmierczak S, Eriksson P, Samnegard A, Farrell D . Elevated plasma fibrinogen gamma' concentration is associated with myocardial infarction: effects of variation in fibrinogen genes and environmental factors. J Thromb Haemost. 2007; 5(4):766-73. DOI: 10.1111/j.1538-7836.2007.02406.x. View

Wolberg A . Thrombin generation and fibrin clot structure. Blood Rev. 2007; 21(3):131-42. DOI: 10.1016/j.blre.2006.11.001. View

Lim B, Ariens R, Carter A, Weisel J, Grant P . Genetic regulation of fibrin structure and function: complex gene-environment interactions may modulate vascular risk. Lancet. 2003; 361(9367):1424-31. DOI: 10.1016/S0140-6736(03)13135-2. View

10.

Swieringa F, Baaten C, Verdoold R, Mastenbroek T, Rijnveld N, van der Laan K . Platelet Control of Fibrin Distribution and Microelasticity in Thrombus Formation Under Flow. Arterioscler Thromb Vasc Biol. 2016; 36(4):692-9. DOI: 10.1161/ATVBAHA.115.306537. View

11.

Allan P, Uitte de Willige S, Abou-Saleh R, Connell S, Ariens R . Evidence that fibrinogen γ' directly interferes with protofibril growth: implications for fibrin structure and clot stiffness. J Thromb Haemost. 2012; 10(6):1072-80. DOI: 10.1111/j.1538-7836.2012.04717.x. View

12.

Aleman M, Byrnes J, Wang J, Tran R, Lam W, Di Paola J . Factor XIII activity mediates red blood cell retention in venous thrombi. J Clin Invest. 2014; 124(8):3590-600. PMC: 4109540. DOI: 10.1172/JCI75386. View

13.

Huffman J, de Vries P, Morrison A, Sabater-Lleal M, Kacprowski T, Auer P . Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF. Blood. 2015; 126(11):e19-29. PMC: 4566813. DOI: 10.1182/blood-2015-02-624551. View

14.

Andia M, Saha P, Jenkins J, Modarai B, Wiethoff A, Phinikaridou A . Fibrin-targeted magnetic resonance imaging allows in vivo quantification of thrombus fibrin content and identifies thrombi amenable for thrombolysis. Arterioscler Thromb Vasc Biol. 2014; 34(6):1193-1198. PMC: 4195984. DOI: 10.1161/ATVBAHA.113.302931. View

15.

Duval C, Ali M, Chaudhry W, Ridger V, Ariens R, Philippou H . Factor XIII A-Subunit V34L Variant Affects Thrombus Cross-Linking in a Murine Model of Thrombosis. Arterioscler Thromb Vasc Biol. 2016; 36(2):308-16. DOI: 10.1161/ATVBAHA.115.306695. View

16.

Henderson S, Xia J, Wu H, Stafford A, Leslie B, Fredenburgh J . Zinc promotes clot stability by accelerating clot formation and modifying fibrin structure. Thromb Haemost. 2015; 115(3):533-42. DOI: 10.1160/TH15-06-0462. View

17.

Campbell R, Overmyer K, Bagnell C, Wolberg A . Cellular procoagulant activity dictates clot structure and stability as a function of distance from the cell surface. Arterioscler Thromb Vasc Biol. 2008; 28(12):2247-54. PMC: 2773697. DOI: 10.1161/ATVBAHA.108.176008. View

18.

Scott D, Prasad P, Philippou H, Rashid S, Sohrabi S, Whalley D . Clot architecture is altered in abdominal aortic aneurysms and correlates with aneurysm size. Arterioscler Thromb Vasc Biol. 2011; 31(12):3004-10. DOI: 10.1161/ATVBAHA.111.236786. View

19.

Stalker T, Welsh J, Tomaiuolo M, Wu J, Colace T, Diamond S . A systems approach to hemostasis: 3. Thrombus consolidation regulates intrathrombus solute transport and local thrombin activity. Blood. 2014; 124(11):1824-31. PMC: 4162112. DOI: 10.1182/blood-2014-01-550319. View

20.

Cines D, Lebedeva T, Nagaswami C, Hayes V, Massefski W, Litvinov R . Clot contraction: compression of erythrocytes into tightly packed polyhedra and redistribution of platelets and fibrin. Blood. 2013; 123(10):1596-603. PMC: 3945867. DOI: 10.1182/blood-2013-08-523860. View