Evaluation of Clinical and Laboratory Markers of Cardiometabolic Risk in Overweight and Obese Children and Adolescents

Overview

Journal Clinics (Sao Paulo)

Publisher Elsevier

Specialty General Medicine

Date 2017 Feb 23

PMID 28226031

Citations 3

Authors

Heloisa Marcelina da Cunha Palhares

Adriana Paula da Silva

Daniela Cristina Silva Resende

Gilberto de Araujo Pereira

Virmondes Rodrigues Junior

Maria de Fatima Borges

Affiliations

Soon will be listed here.

Abstract

Objective:: This study analyzed the frequency of cardiometabolic risk markers and metabolic syndrome occurrence in overweight and obese children and adolescents.

Methods:: The participants included 161 overweight (n=65) and obese (n=96) individuals aged between 5 and 19 years. Clinical markers were assessed (body mass index, body fat percentage, waist circumference, acanthosis, systolic and diastolic blood pressures, laboratory parameters [glucose, insulin, cholesterol (total and fractions) and triglyceride levels and homeostasis model assessment of insulin resistance (HOMA-IR) index] and leptin and adiponectin levels). The frequency of changes, odds ratios and correlations among markers were determined. Metabolic syndrome was assessed according to International Diabetes Federation criteria.

Results:: A high frequency of acanthosis (51.6%); increased waist circumference (45.4%), systolic blood pressure / diastolic blood pressure (8.1% / 9.3%), glucose (10%), insulin (36.9%) and HOMA-IR (44.3%) values; and reduced high-density lipoprotein levels (47.2%) were observed. Leptin levels were increased in 95% of obese and in 66% of overweight subjects. Adiponectin was decreased in 29.5% of obese and in 34% of overweight subjects. An odd ratio analysis revealed a greater probability of increased waist circumference (9.0), systolic blood pressure (4.1), triglyceride (2.3) and insulin (2.9) levels and HOMA-IR (3.0) in the obese group than in the overweight group. The clinical and laboratory parameters and leptin levels exhibited significant correlations, whereas adiponectin was negatively correlated with systolic blood pressure. The occurrence rate of metabolic syndrome was 13.6%.

Conclusions:: The high frequency of changes in clinical, laboratory and adipokine markers indicates the need for early interventions aimed at preventing cardiometabolic complications in adulthood.

Citing Articles

The stability of cardiometabolic risk factors clustering in children and adolescents: a 2-year longitudinal study.

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PMID: 37255777 PMC: 10225448. DOI: 10.1007/s40200-022-01174-1.

Cardiometabolic risk factors among children who are affected by overweight, obesity and severe obesity.

Nur Zati Iwani A, Jalaludin M, Roslan F, Mansor F, Zain F, Hong J Front Public Health. 2023; 11:1097675.

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Leptin trajectories from birth to mid-childhood and cardio-metabolic health in early adolescence.

Li L, Rifas-Shiman S, Aris I, Mantzoros C, Hivert M, Oken E Metabolism. 2018; 91:30-38.

PMID: 30412696 PMC: 6366620. DOI: 10.1016/j.metabol.2018.11.003.

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