Diabetes Mellitus and the Skin

Overview

Journal An Bras Dermatol

Specialty Dermatology

Date 2017 Feb 23

PMID 28225950

Citations 19

Authors

Adriana Lucia Mendes

Helio Amante Miot

Vidal Haddad Junior

Affiliations

Soon will be listed here.

Abstract

Several dermatoses are routinely associated with diabetes mellitus, especially in patients with chronic disease. This relationship can be easily proven in some skin disorders, but it is not so clear in others. Dermatoses such necrobiosis lipoidica, granuloma annulare, acanthosis nigricans and others are discussed in this text, with an emphasis on proven link with the diabetes or not, disease identification and treatment strategy used to control those dermatoses and diabetes.

Citing Articles

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OLaughlin D, McCoy R Clin Diabetes. 2023; 41(3):458-464.

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References

Papa C . Niacinamide and acanthosis nigricans. Arch Dermatol. 1984; 120(10):1281. View

ROCCA F, Pereyra E . Phlyctenar lesions in the feet of diabetic patients. Diabetes. 1963; 12:220-2. DOI: 10.2337/diab.12.3.220. View

Kurwa A, Roberts P, Whitehead R . Concurrence of bullous and atrophic skin lesions in diabetes mellitus. Arch Dermatol. 1971; 103(6):670-5. View

COLE G, Handler S, Burnett K . The ultrasonic evaluation of skin thickness in scleredema. J Clin Ultrasound. 1981; 9(9):501-3. DOI: 10.1002/jcu.1870090907. View

Dabski K, Winkelmann R . Generalized granuloma annulare: clinical and laboratory findings in 100 patients. J Am Acad Dermatol. 1989; 20(1):39-47. DOI: 10.1016/s0190-9622(89)70005-0. View

Ulmer A, Bauer J, Kotter I, Fierlbeck G . [Scleredema adultorum Buschke. Case report and review of the literature]. Hautarzt. 1998; 49(1):48-54. DOI: 10.1007/s001050050700. View

Oumeish O . Skin disorders in patients with diabetes. Clin Dermatol. 2008; 26(3):235-42. DOI: 10.1016/j.clindermatol.2007.10.015. View

Dittmar M, Kahaly G . Polyglandular autoimmune syndromes: immunogenetics and long-term follow-up. J Clin Endocrinol Metab. 2003; 88(7):2983-92. DOI: 10.1210/jc.2002-021845. View

Tsoi L, Spain S, Knight J, Ellinghaus E, Stuart P, Capon F . Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet. 2012; 44(12):1341-8. PMC: 3510312. DOI: 10.1038/ng.2467. View

10.

Moretti S, Spallanzani A, Amato L, Hautmann G, Gallerani I, Fabiani M . New insights into the pathogenesis of vitiligo: imbalance of epidermal cytokines at sites of lesions. Pigment Cell Res. 2002; 15(2):87-92. DOI: 10.1034/j.1600-0749.2002.1o049.x. View

11.

Tamega A, Aranha A, Guiotoku M, Miot L, Miot H . [Association between skin tags and insulin resistance]. An Bras Dermatol. 2010; 85(1):25-31. DOI: 10.1590/s0365-05962010000100003. View

12.

Cohen O, Yaniv R, Karasik A, Trau H . Necrobiosis lipoidica and diabetic control revisited. Med Hypotheses. 1996; 46(4):348-50. DOI: 10.1016/s0306-9877(96)90184-x. View

13.

Armstrong A, Harskamp C, Armstrong E . The association between psoriasis and obesity: a systematic review and meta-analysis of observational studies. Nutr Diabetes. 2012; 2:e54. PMC: 3542430. DOI: 10.1038/nutd.2012.26. View

14.

Alsaeedi S, Lee P . Treatment of scleredema diabeticorum with tamoxifen. J Rheumatol. 2010; 37(12):2636-7. DOI: 10.3899/jrheum.100561. View

15.

Geerlings S, Hoepelman A . Immune dysfunction in patients with diabetes mellitus (DM). FEMS Immunol Med Microbiol. 1999; 26(3-4):259-65. DOI: 10.1111/j.1574-695X.1999.tb01397.x. View

16.

Beattie P, Dawe R, Ibbotson S, Ferguson J . UVA1 phototherapy for treatment of necrobiosis lipoidica. Clin Exp Dermatol. 2006; 31(2):235-8. DOI: 10.1111/j.1365-2230.2005.02059.x. View

17.

Wigington G, Ngo B, Rendell M . Skin blood flow in diabetic dermopathy. Arch Dermatol. 2004; 140(10):1248-50. DOI: 10.1001/archderm.140.10.1248. View

18.

Dwyer C, Dick D . Ulceration in necrobiosis lipoidica--a case report and study. Clin Exp Dermatol. 1993; 18(4):366-9. DOI: 10.1111/j.1365-2230.1993.tb02220.x. View

19.

Sommer D, Jenisch S, Suchan M, Christophers E, Weichenthal M . Increased prevalence of the metabolic syndrome in patients with moderate to severe psoriasis. Arch Dermatol Res. 2006; 298(7):321-8. DOI: 10.1007/s00403-006-0703-z. View

20.

Nieboer C, Kalsbeek G . Direct immunofluorescence studies in granuloma annulare, necrobiosis lipoidica and granulomatosis disciformis Miescher. Dermatologica. 1979; 158(6):427-32. DOI: 10.1159/000250793. View