Kinetin Improves Barrier Function of the Skin by Modulating Keratinocyte Differentiation Markers

Overview

Journal Ann Dermatol

Specialty Dermatology

Date 2017 Feb 23

PMID 28223740

Citations 5

Authors

Sungkwan An

Hwa Jun Cha

Jung-Min Ko

Hyunjoo Han

Su Young Kim

Kyung-Suk Kim

Song Jeong Lee

In-Sook An

Sangwon Kim

Hae Jeong Youn

Kyu Joong Ahn

Soo-Yeon Kim

Affiliations

Soon will be listed here.

Abstract

Background: Kinetin is a plant hormone that regulates growth and differentiation. Keratinocytes, the basic building blocks of the epidermis, function in maintaining the skin barrier.

Objective: We examined whether kinetin induces skin barrier functions and .

Methods: To evaluate the efficacy of kinetin at the cellular level, expression of keratinocyte differentiation markers was assessed. Moreover, we examined the clinical efficacy of kinetin by evaluating skin moisture, transepidermal water loss (TEWL), and skin surface roughness in patients who used kinetin-containing cream. We performed quantitative real-time polymerase chain reaction to measure the expression of keratinocyte differentiation markers in HaCaT cells following treatment. A clinical trial was performed to assess skin moisture, TEWL, and evenness of skin texture in subjects who used kinetin-containing cream for 4 weeks.

Results: Kinetin increased involucrin, and keratin 1 mRNA in HaCaT cells. Moreover, use of a kinetin-containing cream improved skin moisture and TEWL while decreasing roughness of skin texture.

Conclusion: Kinetin induced the expression of keratinocyte differentiation markers, suggesting that it may affect differentiation to improve skin moisture content, TEWL, and other signs of skin aging. Therefore, kinetin is a potential new component for use in cosmetics as an anti-aging agent that improves the barrier function of skin.

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