Effects of Sex and Generation on Hepatitis B Viral Load in Families with Hepatocellular Carcinoma

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2017 Feb 23

PMID 28223732

Citations 6

Authors

Ai-Ru Hsieh

Cathy Sj Fann

Chau-Ting Yeh

Hung-Chun Lin

Shy-Yi Wan

Yi-Cheng Chen

Chia-Lin Hsu

Jennifer Tai

Shi-Ming Lin

Dar-In Tai

Affiliations

Soon will be listed here.

Abstract

Aim: To explore factors associated with persistent hepatitis B virus (HBV) infection in a cohort of hepatocellular carcinoma (HCC)-affected families and then investigate factors that correlate with individual viral load among hepatitis B surface antigen (HBsAg)-positive relatives.

Methods: We evaluated non-genetic factors associated with HBV replication in relatives of patients with HCC. Relatives of 355 HCC cases were interviewed using a structured questionnaire. Demographics, relationship to index case, HBsAg status of mothers and index cases were evaluated for association with the HBV persistent infection or viral load by generalized estimating equation analysis.

Results: Among 729 relatives enrolled, parent generation ( = 0.0076), index generation ( = 0.0044), mothers positive for HBsAg ( = 0.0007), and HBsAg-positive index cases ( = 5.98 × 10) were associated with persistent HBV infection. Factors associated with HBV viral load were evaluated among 303 HBsAg-positive relatives. Parent generation ( = 0.0359) and sex ( = 0.0007) were independent factors associated with HBV viral load. The intra-family HBV viral load was evaluated in families clustered with HBsAg-positive siblings. An intra-family trend of similar HBV viral load was found for 27 of 46 (58.7%) families. Male offspring of HBsAg-positive mothers ( = 0.024) and older siblings were associated with high viral load.

Conclusion: Sex and generation play important roles on HBV viral load. Maternal birth age and nutritional changes could be the reasons of viral load difference between generations.

Citing Articles

Diagnosis experiences from 50 hepatitis B patients in Chongqing, China: a qualitative study.

Zhou X, Zhang F, Ao Y, Lu C, Li T, Xu X BMC Public Health. 2021; 21(1):2195.

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Hepatitis B virus persistent infection-related single nucleotide polymorphisms in HLA regions are associated with viral load in hepatoma families.

Hsieh A, Fann C, Lin H, Tai J, Hsieh S, Tai D World J Gastroenterol. 2021; 27(37):6262-6276.

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Molecular and Biological Mechanisms Underlying Gender Differences in COVID-19 Severity and Mortality.

Wehbe Z, Hammoud S, Yassine H, Fardoun M, El-Yazbi A, Eid A Front Immunol. 2021; 12:659339.

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Hepatitis B Infection: A Mixed Methods of Disclosure Pattern and Social Problems in the Nigerian Family.

Adekanle O, Komolafe A, Olowookere S, Ijarotimi O, Ndububa D J Patient Exp. 2020; 7(2):208-216.

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Sex-Dependent Outcome of Hepatitis B and C Viruses Infections: Synergy of Sex Hormones and Immune Responses?.

Ruggieri A, Gagliardi M, Anticoli S Front Immunol. 2018; 9:2302.

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