The Effect of Lipophilic Amines on the Growth of Hepatitis A Virus in Frp/3 Cells

Overview

Journal Arch Virol

Specialty Microbiology

Date 1987 Jan 1

PMID 2821967

Citations 12

Authors

F Superti

L Seganti

N Orsi

M Divizia

R Gabrieli

A Pana

Affiliations

Soon will be listed here.

Abstract

The effect of lipophilic amines on hepatitis A virus infection in a monkey cell line (Frp/3 cells) was studied. Ammonium chloride, amantadine, methylamine and dansylcadaverine inhibited viral antigen synthesis when added to the cells at least one hour after the attachment step. Results obtained suggest that the HAV entry pathway in Frp/3 cells follows an endocytic route and that viral uncoating takes probably place in endosomes and/or lysosomes.

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