Aspirin-Triggered Resolvin D1-modified Materials Promote the Accumulation of Pro-regenerative Immune Cell Subsets and Enhance Vascular Remodeling

Overview

Journal Acta Biomater

Publisher Elsevier

Specialty Biomedical Engineering

Date 2017 Feb 19

PMID 28213094

Citations 32

Authors

Mary Caitlin P Sok

Maxianne C Tria

Claire E Olingy

Cheryl L San Emeterio

Edward A Botchwey

Affiliations

Soon will be listed here.

Abstract

Statement Of Significance: This work is motivated by our efforts to explore the underlying mechanisms of inflammation resolution after injury and to develop biomaterial-based approaches to amplify endogenous mechanisms of resolution and repair. Though specific lipid mediators have been identified that actively promote the resolution of inflammation, biomaterial-based localized delivery of these mediators has been largely unexplored. We loaded Aspirin-Triggered Resolvin D1 into a PLGA scaffold and examined the effects of sustained, localized delivery on the innate immune response. We found that biomaterial delivery of resolvin was able to enhance the accumulation of pro-regenerative populations of immune cells, including anti-inflammatory monocytes, population that has never before been shown to respond to resolvin treatment, and also enhance vascular remodeling in response to tissue injury.

Citing Articles

Biomaterials for immunomodulation in wound healing.

Wang Y, Vizely K, Li C, Shen K, Shakeri A, Khosravi R Regen Biomater. 2024; 11:rbae032.

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Addition of Resolvins D1 or E1 to Collagen Membranes Mitigates Their Resorption in Diabetic Rats.

Almogy M, Moses O, Schiffmann N, Weinberg E, Nemcovsky C, Weinreb M J Funct Biomater. 2023; 14(5).

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