Precursor N-cadherin Mediates Glial Cell Line-derived Neurotrophic Factor-promoted Human Malignant Glioma

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 Feb 18

PMID 28212546

Citations 7

Authors

Ye Xiong

Liyun Liu

Shuang Zhu

Baole Zhang

Yuxia Qin

Ruiqin Yao

Hao Zhou

Dian Shuai Gao

Affiliations

Soon will be listed here.

Abstract

As the most prevalent primary brain tumor, gliomas are highly metastatic, invasive and are characteristic of high levels of glial cell-line derived neurotrophic factor (GDNF). GDNF is an important factor for invasive glioma cell growth; however, the underlying mechanism involved is unclear. In this study, we affirm a significantly higher expression of the precursor of N-cadherin (proN-cadherin) in most gliomas compared with normal brain tissues. Our findings reveal that GDNF interacts with the extracellular domain of proN-cadherin, which suggests that proN-cadherin mediates GDNF-induced glioma cell migration and invasion. We hypothesize that proN-cadherin might cause homotypic adhesion loss within neighboring cells and at the same time promote heterotypic adhesion within the extracellular matrix (ECM) through a certain mechanism. This study also demonstrates that the interaction between GDNF and proN-cadherin activates specific intracellular signaling pathways; furthermore, GDNF promoted the secretion of matrix metalloproteinase-9 (MMP-9), which degrades the ECM via proN-cadherin. To reach the future goal of developing novel therapies of glioma, this study, reveals a unique mechanism of glioma cell migration and invasion.

Citing Articles

Testosterone upregulates glial cell line-derived neurotrophic factor (GDNF) and promotes neuroinflammation to enhance glioma cell survival and proliferation.

Kanwore K, Kanwore K, Guo X, Xia Y, Zhou H, Zhang L Inflamm Regen. 2023; 43(1):49.

PMID: 37833789 PMC: 10571473. DOI: 10.1186/s41232-023-00300-7.

GDNF triggers proliferation of rat C6 glioma cells via the NF-κB/CXCL1 signaling pathway.

Wang Y, Wu Y, Li L, Gao J, Gao D, Sun S PLoS One. 2023; 18(8):e0289071.

PMID: 37594930 PMC: 10437914. DOI: 10.1371/journal.pone.0289071.

Surface Functionalised Parenteral Nanoemulsions for Active and Homotypic Targeting to Melanoma.

Foglietta F, Bozza A, Ferraris C, Cangemi L, Bordano V, Serpe L Pharmaceutics. 2023; 15(5).

PMID: 37242600 PMC: 10222029. DOI: 10.3390/pharmaceutics15051358.

Pathologic Proteolytic Processing of N-Cadherin as a Marker of Human Fibrotic Disease.

Ferrell P, Oristian K, Cockrell E, Pizzo S Cells. 2022; 11(1).

PMID: 35011717 PMC: 8750447. DOI: 10.3390/cells11010156.

Doublecortin undergo nucleocytoplasmic transport via the RanGTPase signaling to promote glioma progression.

Ayanlaja A, Ji G, Wang J, Gao Y, Cheng B, Kanwore K Cell Commun Signal. 2020; 18(1):24.

PMID: 32050972 PMC: 7017634. DOI: 10.1186/s12964-019-0485-5.

References

Song H, Moon A . Glial cell-derived neurotrophic factor (GDNF) promotes low-grade Hs683 glioma cell migration through JNK, ERK-1/2 and p38 MAPK signaling pathways. Neurosci Res. 2006; 56(1):29-38. DOI: 10.1016/j.neures.2006.04.019. View

Kim J, Islam S, Kim Y, Prudoff R, Sass K, Wheelock M . N-Cadherin extracellular repeat 4 mediates epithelial to mesenchymal transition and increased motility. J Cell Biol. 2000; 151(6):1193-206. PMC: 2190584. DOI: 10.1083/jcb.151.6.1193. View

Singh M, Darcy K, Brady W, Clubwala R, Weber Z, Rittenbach J . Cadherins, catenins and cell cycle regulators: impact on survival in a Gynecologic Oncology Group phase II endometrial cancer trial. Gynecol Oncol. 2011; 123(2):320-8. PMC: 3518446. DOI: 10.1016/j.ygyno.2011.07.005. View

Cao J, Yu J, Li C, Sun Y, Yuan H, Wang H . Integrin beta1 is involved in the signaling of glial cell line-derived neurotrophic factor. J Comp Neurol. 2008; 509(2):203-10. DOI: 10.1002/cne.21739. View

Maret D, Sadr M, Seyed Sadr E, Colman D, Del Maestro R, Seidah N . Opposite roles of furin and PC5A in N-cadherin processing. Neoplasia. 2012; 14(10):880-92. PMC: 3479834. DOI: 10.1593/neo.121250. View

Sawaya R, Go Y, Kyritisis A, Uhm J, Venkaiah B, Mohanam S . Elevated levels of Mr 92,000 type IV collagenase during tumor growth in vivo. Biochem Biophys Res Commun. 1998; 251(2):632-6. DOI: 10.1006/bbrc.1998.9466. View

Golan M, Schreiber G, Avissar S . Antidepressants elevate GDNF expression and release from C₆ glioma cells in a β-arrestin1-dependent, CREB interactive pathway. Int J Neuropsychopharmacol. 2011; 14(10):1289-300. DOI: 10.1017/S1461145710001550. View

Ng W, Wan G, Peng Z, Too H . Glial cell-line derived neurotrophic factor (GDNF) family of ligands confer chemoresistance in a ligand-specific fashion in malignant gliomas. J Clin Neurosci. 2009; 16(3):427-36. DOI: 10.1016/j.jocn.2008.06.002. View

Maret D, Gruzglin E, Sadr M, Siu V, Shan W, Koch A . Surface expression of precursor N-cadherin promotes tumor cell invasion. Neoplasia. 2010; 12(12):1066-80. PMC: 3003141. DOI: 10.1593/neo.10954. View

10.

Kohn E, Liotta L . Molecular insights into cancer invasion: strategies for prevention and intervention. Cancer Res. 1995; 55(9):1856-62. View

11.

Binello E, Mormone E, Emdad L, Kothari H, Germano I . Characterization of fenofibrate-mediated anti-proliferative pro-apoptotic effects on high-grade gliomas and anti-invasive effects on glioma stem cells. J Neurooncol. 2014; 117(2):225-34. DOI: 10.1007/s11060-014-1385-6. View

12.

Hazan R, Qiao R, Keren R, Badano I, Suyama K . Cadherin switch in tumor progression. Ann N Y Acad Sci. 2004; 1014:155-63. DOI: 10.1196/annals.1294.016. View

13.

Shinoura N, Paradies N, Warnick R, Chen H, Larson J, Tew J . Expression of N-cadherin and alpha-catenin in astrocytomas and glioblastomas. Br J Cancer. 1995; 72(3):627-33. PMC: 2033884. DOI: 10.1038/bjc.1995.384. View

14.

Wiesenhofer B, Stockhammer G, Kostron H, Maier H, Hinterhuber H, Humpel C . Glial cell line-derived neurotrophic factor (GDNF) and its receptor (GFR-alpha 1) are strongly expressed in human gliomas. Acta Neuropathol. 2000; 99(2):131-7. DOI: 10.1007/pl00007416. View

15.

Wan G, Too H . A specific isoform of glial cell line-derived neurotrophic factor family receptor alpha 1 regulates RhoA expression and glioma cell migration. J Neurochem. 2010; 115(3):759-70. DOI: 10.1111/j.1471-4159.2010.06975.x. View

16.

Hsu M, Meier F, Nesbit M, Hsu J, van Belle P, Elder D . E-cadherin expression in melanoma cells restores keratinocyte-mediated growth control and down-regulates expression of invasion-related adhesion receptors. Am J Pathol. 2000; 156(5):1515-25. PMC: 1876923. DOI: 10.1016/S0002-9440(10)65023-7. View

17.

Durbec P, Kilkenny C, Grigoriou M, Wartiowaara K, Suvanto P, Smith D . GDNF signalling through the Ret receptor tyrosine kinase. Nature. 1996; 381(6585):789-93. DOI: 10.1038/381789a0. View

18.

Cornejo M, Nambi D, Walheim C, Somerville M, Walker J, Kim L . Effect of NRG1, GDNF, EGF and NGF in the migration of a Schwann cell precursor line. Neurochem Res. 2010; 35(10):1643-51. PMC: 3299396. DOI: 10.1007/s11064-010-0225-0. View

19.

Lilien J, Balsamo J . The regulation of cadherin-mediated adhesion by tyrosine phosphorylation/dephosphorylation of beta-catenin. Curr Opin Cell Biol. 2005; 17(5):459-65. DOI: 10.1016/j.ceb.2005.08.009. View

20.

Safranek J, Pesta M, Holubec L, Kulda V, Dreslerova J, Vrzalova J . Expression of MMP-7, MMP-9, TIMP-1 and TIMP-2 mRNA in lung tissue of patients with non-small cell lung cancer (NSCLC) and benign pulmonary disease. Anticancer Res. 2009; 29(7):2513-7. View