The Tumor Microenvironment at a Turning Point Knowledge Gained Over the Last Decade, and Challenges and Opportunities Ahead: A White Paper from the NCI TME Network

Overview

Journal Cancer Res

Specialty Oncology

Date 2017 Feb 18

PMID 28209610

Citations 20

Authors

Yves A DeClerck

Kenneth J Pienta

Elisa C Woodhouse

Dinah S Singer

Suresh Mohla

Affiliations

Soon will be listed here.

Abstract

Over the past 10 years, the Tumor Microenvironment Network (TMEN), supported by the NCI (Bethesda, MD), has promoted collaborative research with the explicit goal of fostering multi-institutional and transdisciplinary groups that are capable of addressing complex issues involving the tumor microenvironment. The main goal of the TMEN was to generate novel information about the dynamic complexity of tumor-host interactions in different organ systems with emphasis on using human tissues and supplemented by experimental models. As this initiative comes to a close, members of the TMEN took time to examine what has been accomplished by the Network and importantly to identify the challenges and opportunities ahead. This consensus document summarizes for the broader scientific community discussions that occurred at the two final meetings of the TMEN in 2015 and 2016. .

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References

Ayala G, Dai H, Powell M, Li R, Ding Y, Wheeler T . Cancer-related axonogenesis and neurogenesis in prostate cancer. Clin Cancer Res. 2008; 14(23):7593-603. DOI: 10.1158/1078-0432.CCR-08-1164. View

Lakritz J, Poutahidis T, Mirabal S, Varian B, Levkovich T, Ibrahim Y . Gut bacteria require neutrophils to promote mammary tumorigenesis. Oncotarget. 2015; 6(11):9387-96. PMC: 4496224. DOI: 10.18632/oncotarget.3328. View

Chen P, Roh W, Reuben A, Cooper Z, Spencer C, Prieto P . Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade. Cancer Discov. 2016; 6(8):827-37. PMC: 5082984. DOI: 10.1158/2159-8290.CD-15-1545. View

Quante M, Tu S, Tomita H, Gonda T, Wang S, Takashi S . Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth. Cancer Cell. 2011; 19(2):257-72. PMC: 3060401. DOI: 10.1016/j.ccr.2011.01.020. View

Bierie B, Moses H . Transforming growth factor beta (TGF-beta) and inflammation in cancer. Cytokine Growth Factor Rev. 2009; 21(1):49-59. PMC: 2834863. DOI: 10.1016/j.cytogfr.2009.11.008. View

Rivera L, Bergers G . Angiogenesis. Targeting vascular sprouts. Science. 2014; 344(6191):1449-50. DOI: 10.1126/science.1257071. View

Sosa M, Bragado P, Aguirre-Ghiso J . Mechanisms of disseminated cancer cell dormancy: an awakening field. Nat Rev Cancer. 2014; 14(9):611-22. PMC: 4230700. DOI: 10.1038/nrc3793. View

Raja W, Padgen M, Williams J, Gertler F, Wyckoff J, Condeelis J . Development path and current status of the NANIVID: a new device for cancer cell studies. J Micro Nanolithogr MEMS MOEMS. 2014; 11(1). PMC: 4238296. DOI: 10.1117/1.JMM.11.1.013013. View

Yanagisawa N, Li R, Rowley D, Liu H, Kadmon D, Miles B . Stromogenic prostatic carcinoma pattern (carcinomas with reactive stromal grade 3) in needle biopsies predicts biochemical recurrence-free survival in patients after radical prostatectomy. Hum Pathol. 2007; 38(11):1611-20. DOI: 10.1016/j.humpath.2007.04.008. View

10.

Rubin M, Putzi M, Mucci N, Smith D, Wojno K, Korenchuk S . Rapid ("warm") autopsy study for procurement of metastatic prostate cancer. Clin Cancer Res. 2000; 6(3):1038-45. View

11.

van der Toom E, Verdone J, Gorin M, Pienta K . Technical challenges in the isolation and analysis of circulating tumor cells. Oncotarget. 2016; 7(38):62754-62766. PMC: 5308763. DOI: 10.18632/oncotarget.11191. View

12.

Dean J, Nelson P . Profiling influences of senescent and aged fibroblasts on prostate carcinogenesis. Br J Cancer. 2008; 98(2):245-9. PMC: 2361445. DOI: 10.1038/sj.bjc.6604087. View

13.

Naba A, Clauser K, Hoersch S, Liu H, Carr S, Hynes R . The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol Cell Proteomics. 2011; 11(4):M111.014647. PMC: 3322572. DOI: 10.1074/mcp.M111.014647. View

14.

Ozdemir B, Pentcheva-Hoang T, Carstens J, Zheng X, Wu C, Simpson T . Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell. 2014; 25(6):719-34. PMC: 4180632. DOI: 10.1016/j.ccr.2014.04.005. View

15.

Gunderson A, Kaneda M, Tsujikawa T, Nguyen A, Affara N, Ruffell B . Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer. Cancer Discov. 2015; 6(3):270-85. PMC: 4783268. DOI: 10.1158/2159-8290.CD-15-0827. View

16.

Affara N, Ruffell B, Medler T, Gunderson A, Johansson M, Bornstein S . B cells regulate macrophage phenotype and response to chemotherapy in squamous carcinomas. Cancer Cell. 2014; 25(6):809-821. PMC: 4063283. DOI: 10.1016/j.ccr.2014.04.026. View

17.

Ruffell B, Au A, Rugo H, Esserman L, Hwang E, Coussens L . Leukocyte composition of human breast cancer. Proc Natl Acad Sci U S A. 2011; 109(8):2796-801. PMC: 3287000. DOI: 10.1073/pnas.1104303108. View

18.

Bianchi-Frias D, Basom R, Delrow J, Coleman I, Dakhova O, Qu X . Cells Comprising the Prostate Cancer Microenvironment Lack Recurrent Clonal Somatic Genomic Aberrations. Mol Cancer Res. 2016; 14(4):374-84. PMC: 5582956. DOI: 10.1158/1541-7786.MCR-15-0330. View

19.

Rohan T, Xue X, Lin H, DAlfonso T, Ginter P, Oktay M . Tumor microenvironment of metastasis and risk of distant metastasis of breast cancer. J Natl Cancer Inst. 2014; 106(8). PMC: 4133559. DOI: 10.1093/jnci/dju136. View

20.

Melo S, Luecke L, Kahlert C, Fernandez A, Gammon S, Kaye J . Glypican-1 identifies cancer exosomes and detects early pancreatic cancer. Nature. 2015; 523(7559):177-82. PMC: 4825698. DOI: 10.1038/nature14581. View