Inflammatory Milieu and Cardiovascular Homeostasis in Children With Obstructive Sleep Apnea

Overview

Journal Sleep

Publisher Oxford University Press

Specialty Psychiatry

Date 2017 Feb 17

PMID 28204724

Citations 17

Authors

David F Smith

Md M Hossain

Arjan Hura

Guixia Huang

Keith McConnell

Stacey L Ishman

Raouf S Amin

Affiliations

Soon will be listed here.

Abstract

Introduction: Biomarkers of atherosclerosis (pro-inflammatory cytokines and acute phase reactants) are elevated in children with obstructive sleep apnea (OSA). However, their association with cardiovascular endpoints in children are not understood. We hypothesized that biomarkers of atherosclerosis in children with OSA correlate with pulse transit time (PTT), a surrogate measure of vascular stiffness, with some positively influencing and others negatively influencing PTT.

Methods: Children with OSA and matched controls were recruited to the study. Pro-inflammatory cytokines and acute phase reactants were measured at 6:00 pm and 6:00 am. Polysomnography with beat-to-beat blood pressure was performed. PTT during wakefulness and stage 2 sleep was calculated. Diurnal variation of biomarkers and their associations with PTT was estimated. Factor analysis was used to determine the effect of groups of cytokines on PTT.

Results: One hundred fifty-five children participated in the study; 90 were healthy controls and 65 had OSA. Children with OSA exhibited a different diurnal variation of biomarkers than healthy controls, with pro-inflammatory cytokines peaking in the morning and acute phase reactants peaking in the afternoon. Structural equation modeling demonstrated that interleukins 6 and 8, tumor necrosis factor-α, and sCD40L had a shortening effect, while serum amyloid A, C-reactive protein, and adiponectin had a prolonging effect on PTT. As a result, there was no difference in PTT between the two groups.

Conclusion: The differential relationships of acute phase reactants and pro-inflammatory cytokines with PTT suggest that in children with OSA, these mediators may have opposing actions to maintain cardiovascular homeostasis.

Citing Articles

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Association of Tumor Necrosis Factor-Alpha, Interleukin-1β, Interleukin-8, and Interferon-γ with Obstructive Sleep Apnea in Both Children and Adults: A Meta-Analysis of 102 Articles.

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Koritala B, Gaspar L, Bhadri S, Massie K, Lee Y, Paulose J Laryngoscope. 2023; 134 Suppl 4:S1-S11.

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Obstructive sleep apnea in a mouse model is associated with tissue-specific transcriptomic changes in circadian rhythmicity and mean 24-hour gene expression.

Koritala B, Lee Y, Gaspar L, Bhadri S, Su W, Wu G PLoS Biol. 2023; 21(5):e3002139.

PMID: 37252926 PMC: 10228805. DOI: 10.1371/journal.pbio.3002139.

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