Application of a Novel CD206+ Macrophage-Specific Arterial Imaging Strategy in HIV-Infected Individuals

Overview

Journal J Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2017 Feb 17

PMID 28204544

Citations 28

Authors

Markella V Zanni

Mabel Toribio

Moses Q Wilks

Michael T Lu

Tricia H Burdo

Joshua Walker

Patrick Autissier

Borek Foldyna

Lauren Stone

Amanda Martin

Fred Cope

Bonnie Abbruzzese

Thomas Brady

Udo Hoffmann

Kenneth C Williams

Georges El-Fakhri

Steven K Grinspoon

Affiliations

Soon will be listed here.

Abstract

Background: The ability to noninvasively assess arterial CD206+ macrophages may lead to improved understanding of human immunodeficiency virus (HIV)-associated cardiovascular disease.

Methods: We trialed a novel macrophage-specific arterial imaging technique.

Results: We demonstrated colocalization between technetium Tc 99m tilmanocept (99mTc-tilmanocept) and CD206+ macrophages ex vivo. In vivo application of 99mTc-tilmanocept single-photon emission computed tomography/computed tomography revealed high-level 99mTc-tilmanocept uptake across 20.4% of the aortic surface volume among HIV-infected subjects, compared with 4.3% among non-HIV-infected subjects (P = .009). Among all subjects, aortic high-level 99mTc-tilmanocept uptake was related to noncalcified aortic plaque volume (r = 0.87; P = .003) on computed tomographic angiography, and this relationship held when we controlled for HIV status.

Conclusion: These first-in-human data introduce a novel macrophage-specific arterial imaging technique in HIV.

Clinical Trials Registration: NCT02542371.

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Foldyna B, Mayrhofer T, Zanni M, Lyass A, Barve R, Karady J Clin Infect Dis. 2023; 77(12):1676-1686.

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